Application Notes

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Breakthrough Technology for Bottom-Up Proteomics and Small Molecule Research
Tuesday, August 01, 2006
Alexander Makarov Helmut Muenster
High mass resolution is a prerequisite for high mass accuracy. Both are key for the analysis of unknown samples. High resolution enables the separation and detection of isobaric signals that are ... Read More
Rapid Screening of Complex Mixtures by Thin Layer Chromatography–Bioluminescence
Friday, September 01, 2006
Sheryl Marie Verbitski Gerald Thomas Gourdin Larissa Marie Ikenouye James Dewey McChesney
The screening of complex mixtures such as foodstuffs, beverages, dietary supplements, and wastewater for toxins and adulterants or potential biological activity is often expensive and time consuming. Read More
Is This Surface Clean? Cleaning Validation by Direct Spectroscopic Surface Analysis
Friday, September 01, 2006
Mary Thomson Peter Melling
Pharmaceutical manufacturers and formulators must be able to confirm that the equipment they use is clean before it is utilized. Read More
Saving Money on TOC Analyzer Gas Costs
Friday, September 01, 2006
Jennifer Triplett
Total organic carbon analyzers are increasingly popular as an accurate and inexpensive way to test for inorganic and organic carbon contamination in water samples. Read More
The Determination of Perchlorate in Water Using LC-MS-MS
Friday, September 01, 2006
Joseph Romano
Perchlorate is both a naturally occurring chemical and a man-made inorganic ion. Read More
Nitrogen Generation in an Environmental Testing Laboratory
Thursday, September 07, 2006
Phillip Allison
Belmont Labs, located in Englewood, OH, is an environmental testing facility offering analytical services to clients in industry, civil/environmental engineering, and state and local governments. Read More
A CCD Sensor Optimized for Chemiluminescence, Fluorescence, and Brightfield Applications
Monday, October 02, 2006
John Pizzonia
Complete multimodal imaging for applications in chemiluminescence, fluorescence, and brightfield imaging is achieved with the LAS-3000 image analysis system. Read More
The Use of Simple Series Detection in Ion Chromatography and HPLC
Monday, October 16, 2006
Ade Kujore Robert Sandor
Many of us have encountered some IC/HPLC analyses in which the same sample is injected onto two different HPLC/IC systems, in order to ascertain the sample composition, with the only difference ... Read More
Use of a LIMS to Help Manage a Larger Workload With Reduced Staff
Wednesday, November 01, 2006
Carolyn Vaughn
A leading manufacturer of tablets, softgels, and two-piece hard-shells in the nutraceuticals and personal health enhancement market, like other players in the industry, faced the challenge of meeting... Read More
Analytical Separations of Proteins and Peptides Using Immobilized Metal Affinity Chromatography
Wednesday, November 01, 2006
Christopher Pohl Patrick McCarthy Mark Tracy Terry Sheehan
Immobilized metal affinity chromatography (IMAC) is a well-established protein separation technique experiencing expanded use based on new, high-performance analytical phases. Read More
Reducing Cell Culture Costs By Reducing Serum Levels
Wednesday, November 01, 2006
John A. Ryan
Cell culture is a very important research tool today, but one that is also very expensive to use. Read More
Measuring Viscosity in Samples as Small as 100 Microliters: Part 1
Friday, December 01, 2006
Kerem Durdag
Over the years there have been a number of efforts to build solid-state viscosity sensors for both laboratory and on-line applications that would measure smaller sample sizes, as well as be easier to... Read More
A Sterile, Reliable Laboratory Setup for Low-Volume Tuberculosis Antibiotic Discovery Assays
Monday, January 01, 2007
Pamela Thayalan Kakoli Mukherjee David Beer
One-third of the world’s population is infected with tuberculosis, and one person dies every 15 sec from the disease. Read More
Increased Throughput in Method 8270 Analysis
Monday, January 01, 2007
William D. Goodman Frank DeLorenzo
Method 8270 is a GC-MS method created by the U.S. EPA Office of Solid Waste for the analysis of semivolatile organics by gas chromatography-mass spectrometry. Read More
Automated Chemical Ionization in GC-MS
Monday, January 01, 2007
Chris Sandy Jean-Francois Garnier Bernhard Rothweiler Fred Feyerherm Sihem Ben Mahmoud Harry F. Prest
Gas chromatography with mass spectrometric detection using chemical ionization (CI) has demonstrated great utility in a wide variety of application areas ranging from forensics to environmental to ... Read More
Centrifuge Safety and Security
Thursday, February 01, 2007
Tammy Goodman
For laboratories around the world, increasing health and safety legislation requires that equipment be operated and maintained so that every step is taken to maximize safety and security. Read More
Reagent-Free Ion Chromatography Systems With Eluent Regeneration: RFIC-ER Systems
Thursday, February 01, 2007
Yan Liu Zhongqing Lu Chris Pohl John Madden Navette Shirakawa
Since the introduction of ion chromatography (IC) in 1975, Dionex Corp. (Sunnyvale, CA) has continued to improve the performance of IC systems while developing new capabilities for the determination ... Read More
From Desert Storm to Lipstick: Applying Viscosity Measurement to New Challenges*
Thursday, February 01, 2007
Kerem Durdag
The development of solid-state acoustic viscometers opens a wide range of new applications in both the laboratory and the field. Read More
Lead in Vinegar: Determination and Possible Sources
Thursday, February 01, 2007
Kuria Ndung’u Sharon Hibdon A. Russell Flegal
Exposure to contaminant lead remains a public concern because of its pervasiveness in the environment and increasing evidence of its sublethal toxicities at exposure levels lower than previously ... Read More
Ion Exchange for Proteomics
Thursday, February 01, 2007
Xueying Huang Virginia McKay
Ion exchange is particularly well suited to the separation of biological molecules; however, limitations of HPLC packing materials have restricted its use. Silica-based ion-exchange materials are pH ... Read More