Application Notes

Complex sample mixtures have always been a challenge for the analytical chemist. Read More

Protein homogeneity is an important issue in many fields of research, be it the characterization of newly isolated molecules, the identification of crystallizable samples, or the preparation of ... Read More

The simultaneous detection of several peptides or proteins in mixtures is an integral part of expression proteomics investigations. Read More

The understanding of protein dynamics, the way these molecules fold to form a stable structure, interact with other molecules, or undergo changes during enzyme activity, etc., in their native ... Read More

The first step in developing effective pharmaceutical formulations is the discovery of the active agent. Read More

Gas chromatography is a simple yet powerful technique for analyzing complex mixtures of volatile and semivolatile compounds. Read More

Assays that predict passive absorption of orally administered drugs have become increasingly important in the early drug discovery process. Read More

A significant responsibility for the analytical group within Drug Discovery Chemistry at Bristol Myers-Squibb (Princeton, NJ) is the chromatographic purification of chiral compounds, both ... Read More

The trend in many of today’s laboratories is toward high throughput and low-volume samples. Read More

Differential scanning calorimetry (DSC) is used to determine thermodynamic properties including specific heat, glass transition, and melting points of a variety of materials. The need for accurate ... Read More