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Title
Compact HPLC Systems for the Analysis of Pesticides, Dyes and Drugs
Friday, January 20, 2017
Vlad Orlovsky
Yury Zelechonok
Konstantin Tchalukov
The analyzer described in this article provides fast analysis of food dyes commonly used in products in the beverage and pharmaceutical industries, as well as high-resolution separation of a complex ...
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Integration of a Dilution Module in a Mass Spectrometry-Based Online Reaction Monitoring System
Friday, January 20, 2017
Heidi Fleischer
Kerstin Thurow
Vinh Quang Do
Dany Hoffmann
A dilution module based primarily on a mass rate attenuator solves the problem of high concentration solution to the mass spectrometer. The low-flow compensation approach was used to circumvent the ...
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NGS Library Validation Using Automated Capillary Gel Electrophoresis
Friday, November 11, 2016
Varouj Amirkhanian
Eric Tsai
Jemmie Chang
Alice Lin
Next-generation sequencing (NGS) is widely used in genomics, epigenetics and transcriptomics, etc., and also in such clinical diagnostics applications as cancer screening and drug development.
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For Accurate Cell-Based Assay Results, Transfer Technique Matters
Wednesday, November 09, 2016
John Lesnick
From smaller-scale assays to industrial-scale screening operations, cell-based assays are critical for applications that include elucidating basic mechanisms of cell function, target validation and ...
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Ten Tips for Proper Pipetting
Monday, November 07, 2016
A. Björn Carle
Pipetting proficiency is one of the most critical elements to ensure accuracy and precision, particularly in the face of high personnel turnover, growing laboratory workloads and increasingly complex ...
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The Myths and Truths of Measuring Pure Water
Monday, November 07, 2016
Gayle Gleichauf
Kim Knepper
Techniques such as liquid chromatography and mass spectrometry require ultrapure water (UPW) for trace-level analysis.
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Achieving Accuracy and Reproducibility With Electronic Pipettes
Monday, November 07, 2016
Nora Meneceur
Beatrice Guieu-Presle
Researchers are continuously seeking ways to improve efficiency while ensuring that their methods are reliable and their research is reproducible.
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Extraction of Planar Pesticides From Spinach and Fresh Oregano Using QuEChERS Methodology With a Novel Carbon Adsorbent
Monday, November 07, 2016
Michael Ye
Jennifer Claus
Although vital to plant life, the presence of chlorophyll in GC/MS analysis is highly problematic.
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
Friday, November 04, 2016
Michael Kowalski
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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Closing the Consumption Gap: Making GC More Accessible
Friday, November 04, 2016
Eric Denoyer
Paul Deitrick
Gas chromatography users agree on at least two things: that GC is a mature technology, and that the performance and features of instrumentation largely meet the application requirements for which GC ...
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High-Throughput Drug Screening of Multicellular Tumor Spheroids
Tuesday, September 27, 2016
Ana Maria P. Pardo
Hannah J. Gitschier
David H. Randle
Terry Riss
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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Exploring the Value of GPC/SEC in Polysaccharide Characterization
Tuesday, September 27, 2016
Stephen Ball
Examples of polysaccharides, widely used as food additives and in certain medical applications, include derivatives of cellulose and starch, such as hydroxymethyl cellulose and maltodextrin, ...
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Comparative QC Test Methods for Toothpaste Consistency
Tuesday, September 27, 2016
Robert McGregor
Important quantitative data can be obtained in the study of viscosity by measuring the consistency of toothpaste, i.e., thickness, ease of handling and ability to retain position, and observing the ...
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Statistics in the Laboratory: The Capability of a Measurement Process
Tuesday, September 27, 2016
Stanley N. Deming
Measurement processes must be fit for use. In this column, we’ll develop some quantitative statistical descriptors of the capability of a measurement process to be valid for its intended purpose.
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Urinary Drug Testing: Small Changes for Big Improvements in Sensitivity
Tuesday, September 27, 2016
Jenny Cybulski
An oversight or mistake in drug testing can have dire consequences—a positive drug test can ruin the possibility of employment, turn an accident into a lawsuit, or cause a physician to discontinue ...
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Weighing in on Weighing
Monday, September 26, 2016
Thomas Pertsch
Steffen Gloth
Weighing ingredients properly is a critical part of manufacturing pharmaceutical products.
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2-D NMR Developments Improve Monoclonal Antibody Characterization
Monday, September 26, 2016
Kimberly L. Colson
Ten years ago, industry commentators noted the increasing importance of biologics, and monoclonal antibodies (mAbs), in particular.
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Reducing Solvent Emissions in the Laboratory
Monday, September 26, 2016
Amy Valladares
Processes such as concentration and evaporation generate tons of solvent vapors annually that are released into the atmosphere.
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High-Pressure Ion Chromatography Enables Fast, Reliable Analysis of Inorganic Cations and Ammonium in Environmental Water Samples
Thursday, September 01, 2016
Carl Fisher
Common alkali and alkaline earth cations are not considered primary drinking water contaminants, but alkaline water can potentially interfere with water clarification and disinfection procedures and ...
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Automated Chromatographic Solid-Phase Extraction Using an Autosampler
Thursday, September 01, 2016
Mark Hayward
Jonathan Ho
Rick Youngblood
Matthew T. Hardison
Tom Moran
Kim Gamble
Solid-phase extraction (SPE) is a preferred tool for isolating target analytes from complex matrices because the availability of a diverse range of chromatographic sorbents enables targeted approaches...
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