Application Notes

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Long-Range Genomics Is Reviving a Lost Art
Wednesday, July 26, 2017
Chris Boles
The instrument described here was designed to treat DNA gently enough that users can prepare libraries of extremely large fragments directly from blood samples, bacterial and tissue cultures, or other... Read More
A Real-Time Concentration Monitor for Flowing Streams
Wednesday, July 26, 2017
Gary W. Yanik Necmi Bugdayci Soydan Kavraal
A real-time concentration monitor will improve the benefits of continuous processing and analysis by reducing or eliminating the need for sample extractions and off-line analyses. Read More
Quantitation Without Calibration—Eliminating the Requirement for Calibration Curves in the GC-FID Analysis of Ethanol in Blood, Urine, and Serum
Wednesday, July 26, 2017
Charlie Spanjers Gregory C. Janis
A catalytic microreactor and flame ionization detector enabled accurate analytical quantitation without the analytical overhead or potential inaccuracy associated with the use of a calibration curve. Read More
Determination of Calcium and Trace Metals in Clogged Biliary Endoprostheses Using ICP/MS
Wednesday, July 26, 2017
Heidi Fleischer Kerstin Thurow Mareike Warkentin Kinjal Ramani Sergej Bauer Detlef Behrend
This article describes a method used to determine calcium and trace metals using inductively coupled plasma/mass spectrometry (ICP/MS) to investigate the elementary composition of encrustations in ... Read More
Manufacturing Considerations for IVD Reagents Used in Clinical Chemistry and Special Chemistry Laboratories
Tuesday, July 25, 2017
Robert J. Janetschek Julia Nisbet-Fahy Andrew Whitehouse
To produce diagnostic reagents that meet current and future demands requires a knowledge, understanding, and appreciation of the various reagents used for clinical testing applications. Read More
An Effective Treatment Strategy for Cytokine Storm in Severe Influenza
Tuesday, July 25, 2017
Erin Murphy
Despite the use of vaccines and antiviral therapies such as oseltamivir, severe influenza kills thousands to tens of thousands of Americans each year. Read More
A Field-Portable Bioanalysis System
Tuesday, July 11, 2017
Varouj Amirkhanian Eric Tsai Alice Lin
A portable bioanalysis system provides high resolution and high detection sensitivity, and is a cost-effective solution for the field detection of pathogens. Read More
Maintaining a Quality System in the Clinical Laboratory
Thursday, June 29, 2017
Ginger Weeden
Communication, collaboration, and thorough preparation are essential to developing a quality system. Read More
Pesticide Testing for the Cannabis Industry: The Importance of LC-MS/MS for Obtaining Accurate Results in a Complex Matrix
Wednesday, June 07, 2017
David Egerton Paul C. Winkler Craig Butt April Quinn-Paquet K.C. Hyland Phil Taylor David Monk
High-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as the method of choice for pesticide analysis because it offers superior selectivity, sensitivity, and ... Read More
A New Era in Filtered Fume Enclosure Safety
Wednesday, June 07, 2017

The latest ductless filtered fume enclosures are a vital resource in the safe and effective operation of modern industrial, educational, hospital, forensic, and pharmaceutical scientific laboratories. Read More
Statistics in the Laboratory: The Limit of Detection
Wednesday, June 07, 2017
Stanley N. Deming
The phrase “limit of detection” sounds so simple, yet it leads to one of the biggest, murkiest, most frustrating swamps in the statistical literature. Read More
What Is Shear Rate and Why Is It Important?
Wednesday, June 07, 2017
David Moonay
Proper equipment selection may allow significantly different materials to be tested with one machine and geometry, merely by changing the testing speed or shear rate. Read More
Using Raman Spectroscopy for Gemstone Analysis
Wednesday, June 07, 2017
Frank J. Yang Gerard Pereira Liang Don Chen
Raman spectroscopy is a nondestructive, extremely fast and low-cost option for gemstone analysis. Read More
How to Avoid Size Mismatch Between Solutes and Column Pores for Optimum HPLC Performance
Wednesday, June 07, 2017
Richard A. Henry Stephanie Schuster
This article describes a new approach for selecting optimum column pores for separating large molecules without losing high performance. Read More
Scalable Synthesis Technology
Wednesday, June 07, 2017
Philipp Wenter
A DNA synthesis platform addresses the need for smaller-scale oligo production without sacrificing quality, accuracy or turnaround time. Read More
Particulate Analysis of Liquid Filtration Materials and Residues in Food Using FTIR Microscopy
Thursday, June 01, 2017
Michael Bradley Steve Lowry
Two sets of analyses are presented—one involving liquid filtration and the other examining particulate residues in food items—using a simple-to-operate FTIR microscope and attenuated total reflection ... Read More
Fume Hoods and Cabinets
Friday, May 19, 2017

Biological safety cabinets and fume hoods protect samples, personnel and the laboratory environment from harsh chemicals or infectious substances. Read More
A Redesigned Confocal Microscope for Super-Resolution Microscopy
Tuesday, May 09, 2017
Erik Manders Peter Drent Ronald Breedijk
A simple optical redesign converts a standard confocal microscope to a super-resolution microscope. Read More
Managing the Complexity of Microbial Biofuel Production With Integrated Informatics
Tuesday, May 09, 2017
Barbara van Cann
Integrated informatics solutions based on LIMS and chromatography data systems are helping biofuel producers ensure that processes are robust, safe and efficient. Read More
Best Practices: Incubators
Monday, May 08, 2017
Nancy Klimpel
Important parameters to consider when selecting an incubator are temperature accuracy, stability and uniformity. Read More