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Statistics in the Laboratory: The Minimum Consistently Detectable Amount
Tuesday, September 05, 2017
Stanley N. Deming
In the previous column we discussed the limit of detection LD, the minimum signal strength above which we can be confident that analyte is present, but with a small false positive risk a that analyte ... Read More
Strategies for Deep Imaging With Multiphoton Microscopy
Wednesday, May 02, 2018
Carlo Amadeo C. Alonzo
Multiphoton microscopy can inform strategies for maximizing depth penetration through highly scattering specimens. Read More
Streamlined Protein Purification
Friday, November 02, 2018
Tom Valorose
Innovative spin device designs minimize or potentially eliminate the incidence of protein aggregation. Read More
Super-Resolution Microscopy Helps Extend Optical Observation Beyond Its Theoretical Boundaries
Wednesday, March 09, 2016
Russell Ulbrich
Scientists have long needed to view structures and processes that cannot be resolved via traditional optical microscopy. Read More
Super-Resolution Microscopy Techniques Combine to Clarify Spatiotemporal Structure of the Endoplasmic Reticulum
Friday, February 17, 2017
Robert L. Stevenson, Ph.D.
Super-resolution microscopy encompasses several new techniques for direct spatiotemporal imaging of structural features much smaller than the diffraction limit of light. The endoplasmic reticulum (ER)... Read More
Supporting Pharmaceutical Cleaning Validation With TOC and UV-VIS Spectrophotometric Analysis
Friday, October 01, 2010
Richard H. Clifford
Quality control and product safety are paramount in the manufacture of pharmaceutical products. Therefore, it is essential that substances other than those approved for a product are not included with... Read More
Synthesis of Mn²⁺-Doped PbS Quantum Dots and Their Spectroscopic Properties
Tuesday, February 01, 2005
Curtis Deer Raymond Sung Pedro Gonzalez Beerman Subra Muralidharan
Quantum dots are semiconductor nanocrystals that have size-dependent properties, unlike bulk materials, as indicated by the well-studied CdSe system. Read More
Synthesis, Characterization, and Evaluation of a Fluid Loss Agent for High-Temperature Drilling Fluid
Thursday, November 07, 2013
Xiuhua Zheng Shiwei Yang Zhongli Lei
Polymers and inorganic additives have been widely used in high-temperature water-based drilling fluids to transport rock cuttings, maintain well stability, control rheological properties, and minimize... Read More
Take the Laboratory With You: Portable XRF
Thursday, February 26, 2009
Jeffrey Henseler
Energy dispersive X-ray fluorescence (ED-XRF) instruments perform nondestructive analysis of a wide range of elements with accuracy and precision. They are relatively inexpensive and are an excellent ... Read More
Techniques for Identifying Food Adulteration and Contamination
Friday, May 22, 2015
Gretchen Shearer
Adulteration and contamination are ongoing concerns in the food and beverage industry, as they can result in unsafe products and damage brand integrity. Small particulate or light filth contamination ... Read More
Ten Steps to Maintaining Gas Stream Purity
Friday, September 23, 2005
Frank Kandl
Many problems in gas chromatography follow a cylinder change-out, prompting chemists to buy ever-higher purity grades of gas. Read More
Ten Tips for Proper Pipetting
Monday, November 07, 2016
A. Björn Carle
Pipetting proficiency is one of the most critical elements to ensure accuracy and precision, particularly in the face of high personnel turnover, growing laboratory workloads and increasingly complex ... Read More
TERS—Ready or Not?
Thursday, September 01, 2016
Barbara Foster
Tip-enhanced Raman spectroscopy, or TERS, integrates scanning probe microscopy (SPM) for nano-scale imaging with confocal Raman spectroscopy for chemical characterization. Read More
Testing and Troubleshooting Liquid Chromatography Method Transfer
Friday, November 10, 2017
Paula Hong Jinchuan Yang Mark Benvenuti Gareth Cleland Patricia McConville
Factors that affect method transfer are discussed, particularly as they relate to the analysis of isoflavones in soy extract. Read More
Testing Viscosity in Chocolates: New Methods to Reliably Meet Industry Standards
Wednesday, February 14, 2018
Klaus Oldoerp
The latest advancements in rheological instrumentation have enabled food manufacturers to test viscosity in chocolate products faster and more reliably than previously. Read More
TGA With Evolved Gas Analysis
Saturday, January 01, 2005
Tom Basalik
In thermogravimetric analysis (TGA), the weight of a sample is recorded as a function of temperature or time under defined atmospheric conditions. Read More
The Benefits of HPLC Coupled With Mass Spectrometry for the Direct Quantitation of Underivatized Amino Acids
Monday, April 04, 2016
Chi Man Ng Wilhad M. Reuter
Amino acids are critical biological components having multiple metabolic functions, particularly when linked together to form proteins, and have any number of important roles. Read More
The Benefits of Machine Washing Laboratory Glassware Versus Hand Washing
Wednesday, October 01, 2008
Lisa Choplo
If the aim of the laboratory is to be cost-efficient and provide consistent results, hand washing should not be the process of choice for cleaning laboratory glassware. Read More
The Challenge of Integrating Information Management Systems Into the Enterprise: How to Make Faster, More Informed Business Decisions With Data
Saturday, March 01, 2008
Trish Meek Séamus Mac Conaonaigh Colin Thurston
One of the most common reasons for purchasing a laboratory information management system (LIMS) is its ability to integrate with laboratory instrumentation and enterprise systems for better data ... Read More
The Cytochrome P450 System and Patient-Specific Pharmacotherapy
Wednesday, June 19, 2013

A portion of the more than 50 Cytochrome P450, or CYP450, enzymes are quite important from a clinical standpoint. This article looks at the role of CYP450 enzymes in drug–drug interactions and ... Read More