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Title
Evaluation of an Automated Solid-Phase Extraction Method Using Positive Pressure
Wednesday, April 08, 2015
Heidi Fleischer
Kerstin Thurow
Ellen Vorberg
Carolin Gallert
Thomas Roddelkopf
Steffen Junginger
Investigations for the determination of drugs in real samples, while gaining in importance, are limited by time and sample throughput. In response to this, the authors developed an automated solid-...
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Simplified Bioanalytical Sample Preparation
Wednesday, April 08, 2015
Erica Pike
The complexity of biological samples can pose challenges to downstream analysis in the pharmaceutical industry. Bioanalytical and drug metabolism and pharmacokinetics (DMPK) groups often work with ...
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Application of HPLC in the Synthesis of 2,4,5-Trifluorobenzoic Acid
Monday, April 20, 2015
Yun Wang
Wen-Yi Su
Yan-Li Xi
An important fine chemical intermediate for pharmaceuticals, agrichemicals and polymers, 2,4,5-trifluorobenzoic acid (2,4,5-TFBA) is synthesized from tetrachlorophthalic anhydride via hydrolysis, ...
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An Automated System to Improve Western Blot Processing
Wednesday, April 22, 2015
Alexander Margulis
Angela M. Zaorski
David P. Chimento
Russ Yukhananov
Western blot assays provide important information about the presence and levels of protein expression. The first step in the procedure is the lysis of cells or tissues followed by solubilization of ...
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Portable Raman Microscopy: Laboratory-Quality Results Measured Anywhere
Wednesday, April 22, 2015
Barbara Foster
While handheld portable Raman is now well established, until recently, microRaman had yet to make the leap out of the laboratory and into the world at large. To meet that challenge, BioTools (Jupiter...
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Identification of Microplastics in the Marine Environment by Raman Microspectroscopy and Imaging
Tuesday, April 28, 2015
Dieter Fischer
Andrea Kaeppler
Klaus-Jochen Eichhorn
Each year, 5–13 million tons of plastic debris enter the oceans. The main reason for this is the inappropriate disposal of waste from industrialized nations.
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How to Choose Between a CCD and sCMOS Scientific-Grade Camera
Wednesday, April 29, 2015
James Joubert
Cell biologists require microscopy tools that can detect rapid movements within a cell with detail and sensitivity in low light conditions. Developers must address performance requirements, and be ...
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Applications of LC/MS for the Determination of Flavanols in Cocoa and Other Selected Foods
Friday, May 01, 2015
W. Jeffrey Hurst
There continues to be a great deal of interest in the flavanol class of compounds, especially in catechin and epicatechin, which are the monomeric and enantiomer members of the class differing only ...
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Thin-Layer Chromatography/Mass Spectrometry Analysis of Sample Mixtures Using a Compact Mass Spectrometer
Tuesday, May 12, 2015
Changtong Hao
Nigel Sousou
Daniel Eikel
Jack Henion
Thin-layer chromatography (TLC) is a planar chromatographic technique used to separate the components of a mixture by employing a thin stationary phase supported by an inert backing. It can be ...
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Techniques for Identifying Food Adulteration and Contamination
Friday, May 22, 2015
Gretchen Shearer
Adulteration and contamination are ongoing concerns in the food and beverage industry, as they can result in unsafe products and damage brand integrity. Small particulate or light filth contamination ...
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Innovative Laboratory Technologies Facilitate Rapid Responses to Public Health Threats Due to Food Adulteration
Tuesday, May 26, 2015
Alex L. Brandt
It was late summer 2008 in China, and Beijing was abuzz as it prepared to host the Summer Olympic Games. However, just as the nation was gearing up to take center stage in one of the brightest moments...
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Screening Live Cells Using RNA Detection Probes
Friday, June 12, 2015
Don Weldon
Harald Lahm
RNA expression is the next frontier in biomarker development because it offers an indication of cellular intent. mRNA expression, in particular, can show how a cell responds to its environment or ...
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Use of Heat Stabilization to Preserve Lipids and Improve Sample Quality
Friday, June 12, 2015
Marcus Söderquist
Lipids have long been considered to be mere building blocks of cell membranes or energy-storage molecules. It is now evident, however, that these small, nonpolymeric molecules play several key roles ...
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Automating and Validating Analysis in High-Throughput Single-Cell Assays
Monday, June 15, 2015
Ian Taylor
Jay Almarode
Michael D. Stadnisky
While genomics and transcriptomics provide insight into the potential of a cell, single-cell phenomic data reflect its current reality, allowing researchers to determine how genomic variants affect ...
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Analysis of Opioids Using Isotope Dilution With GC/MS/MS
Monday, June 15, 2015
Richard Whitney
Laura Chambers
Developing methods for the analysis of drugs of abuse has become a priority for forensic toxicology and law enforcement. The large variety of illicit drugs and new and so-called “designer drugs” has ...
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Liquid Biopsy Solutions for Noninvasive Molecular Profiling
Monday, June 22, 2015
Michael Schwartz
Liquid biopsy offers the potential to understand and treat cancer in ways never before possible. The concept is simple: collect tumor DNA after it enters the peripheral blood circulation and identify...
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Linear Transformation Applied to the Calibration of Analytes in Various Matrices Using a Total Hydrocarbon Analyzer
Friday, July 24, 2015
Michael T. Tang
Grace Feng
Greg Merideth
Rui Huang
Total hydrocarbon analyzers provide linear responses to methane and other hydrocarbons; however, the slope and intercept measurements are dependent on the matrix. This requires that calibration be ...
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Reference Standards Address Technical Challenges in DNA Resequencing
Tuesday, August 04, 2015
Natalie A. LaFranzo
The extensive workflow required to analyze DNA samples using next-generation sequencing (NGS) leaves many opportunities for the introduction of variability.
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A Review of Quetzal: A Linguistic Search Engine for Biomedical Literature
Wednesday, August 05, 2015
C. Tobin Magle
Quetzal is a biomedical literature search engine that uses simple strategies that contain few keywords combined with an extensive biomedical vocabulary and filter sets that mirror the discovery ...
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A Tandem Approach to TOC Analysis in Drinking Water Treatment
Friday, August 07, 2015
John Welsh, Jr.
In 1974 Congress passed the Safe Drinking Water Act (SDWA) to regulate the nation’s drinking water supply.
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