Application Notes

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Lead in Vinegar: Determination and Possible Sources
Thursday, February 01, 2007
Kuria Ndung’u Sharon Hibdon A. Russell Flegal
Exposure to contaminant lead remains a public concern because of its pervasiveness in the environment and increasing evidence of its sublethal toxicities at exposure levels lower than previously ... Read More
Light Microscopy in the Chemistry Laboratory
Tuesday, April 01, 2008
Andrew M. Bowen Sebastian B. Sparenga
The polarized light microscope (PLM) is an extremely powerful instrument for the analysis of many chemical systems. Read More
LIMS and DNA Analysis in the Forensics Laboratory
Tuesday, February 17, 2015
Robin Gall
Laboratory information management systems (LIMS) are valuable tools in the forensics laboratory, streamlining the documentation and management of evidence including sample accession, extraction, ... Read More
LIMS-BPMS Coupling: A Novel Approach for Flexible End-to-End Workflow Automation in Life Science Laboratories, Part 1
Tuesday, March 11, 2014
Kerstin Thurow Silke Holzmüller-Laue Bernd Göde
Generalized life science automation (LSA) includes all application areas of laboratory automation, i.e., health care, pharmaceutical development, chemistry, and biology. The connection of all ... Read More
LIMS-BPMS Coupling: A Novel Approach for Flexible End-to-End Workflow Automation in Life Science Laboratories, Part 2
Monday, August 04, 2014
Kerstin Thurow Silke Holzmüller-Laue Bernd Göde
This article illustrates the potential of coupling a business process management system (BPMS) and LIMS, was presented in Part 1 of this paper (Am. Lab. 2014, 46[4], 26–9). Part 2 highlights the ... Read More
Linear Transformation Applied to the Calibration of Analytes in Various Matrices Using a Total Hydrocarbon Analyzer
Friday, July 24, 2015
Michael T. Tang Grace Feng Greg Merideth Rui Huang
Total hydrocarbon analyzers provide linear responses to methane and other hydrocarbons; however, the slope and intercept measurements are dependent on the matrix. This requires that calibration be ... Read More
Liquid Biopsy Solutions for Noninvasive Molecular Profiling
Monday, June 22, 2015
Michael Schwartz
Liquid biopsy offers the potential to understand and treat cancer in ways never before possible. The concept is simple: collect tumor DNA after it enters the peripheral blood circulation and identify... Read More
Liquid Handling Uses Acoustic Droplet Ejection for Improved Results
Monday, May 08, 2017
Mark Fischer-Colbrie
Acoustic drop ejection systems can pave the way for entirely new applications, bringing higher throughput and greater flexibility to many areas of biology. Read More
Long Reads and the Return of Reference Genomes
Thursday, February 18, 2016
Chris Boles Jonas Korlach
The availability of inexpensive, massively parallel short-read sequencers shifted the focus of high-quality reference genome production to resequencing and draft genome assemblies, emphasizing ... Read More
Long-Range Genomics Is Reviving a Lost Art
Wednesday, July 26, 2017
Chris Boles
The instrument described here was designed to treat DNA gently enough that users can prepare libraries of extremely large fragments directly from blood samples, bacterial and tissue cultures, or other... Read More
Long-Range Sequencing is Required to Unlock the Full Genome
Friday, February 19, 2016
Michael Schnall-Levin
Next-generation sequencing (NGS) provides unprecedented access to one of biology’s greatest mysteries—the genome. Read More
Losses of Proteins in Gradient HPLC
Friday, August 24, 2018
Steven C. Goheen Jacqueline Hilsenbeck-Fajardo
Gradient elution of biopolymers by HPLC is an effective method for separation and quantitation. Read More
Lower Pollution Limits and Refinery Flare Monitoring Require Special Gas Control Equipment for Sampling
Tuesday, April 05, 2016
Larry Gallagher
Implementation of Title 40 of the Clean Air Act has resulted in a dramatic reduction in critical air pollutants. Read More
Maintaining a Quality System in the Clinical Laboratory
Thursday, June 29, 2017
Ginger Weeden
Communication, collaboration, and thorough preparation are essential to developing a quality system. Read More
Making Surface Tension Measurement a Practical Utility for Modern Industrial R&D
Thursday, December 01, 2005
Christoffer Johans Ilkka Palonen Pekka Suomalainen Paavo K.J. Kinnunen
Vast numbers of new surfactants are introduced annually for improved formulation and functionality in products ranging from personal care (e.g., soaps, shampoos, sun care, and cosmetics products), ... Read More
Managing Laboratory Maintenance
Tuesday, February 07, 2006
L. Wayne Collins
Other than personnel-related costs, maintenance is generally the most expensive item in the laboratory operating budget. Read More
Managing the Complexity of Microbial Biofuel Production With Integrated Informatics
Tuesday, May 09, 2017
Barbara van Cann
Integrated informatics solutions based on LIMS and chromatography data systems are helping biofuel producers ensure that processes are robust, safe and efficient. Read More
Managing Workstation Exhaust at Biosafety Level Laboratories
Monday, April 03, 2006
Paul A. Tetley
Biosafety level laboratories, particularly Levels3 and 4, present special problems for managing workstation fumehood exhaust. Read More
Manufacturing Considerations for IVD Reagents Used in Clinical Chemistry and Special Chemistry Laboratories
Tuesday, July 25, 2017
Robert J. Janetschek Julia Nisbet-Fahy Andrew Whitehouse
To produce diagnostic reagents that meet current and future demands requires a knowledge, understanding, and appreciation of the various reagents used for clinical testing applications. Read More
Maple Syrup Color Analysis Using UV/VIS Spectrophotometry
Tuesday, November 24, 2015
Jeff Head John Kinyunjui Mark Talbott Robert Clifford
UV/VIS spectrophotometry is a valuable tool for measuring the properties of liquids and solids. Read More