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Three-Dimensional Co-Culture More Closely Mimics in vivo Interactions of Breast Cancer to Aid Drug Discovery
Wednesday, July 26, 2017
Lubna Hussain Ying Nie Krista Garner
Human mammary epithelial cells and human mammary fibroblasts can be successfully grown in a 3-D co-culture system to mimic the heterotypic interactions of breast cancer cells and stromal cells in vivo... Read More
Pesticide Testing for the Cannabis Industry: The Importance of LC-MS/MS for Obtaining Accurate Results in a Complex Matrix
Wednesday, June 07, 2017
David Egerton Paul C. Winkler Craig Butt April Quinn-Paquet K.C. Hyland Phil Taylor David Monk
High-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as the method of choice for pesticide analysis because it offers superior selectivity, sensitivity, and ... Read More
Maintaining a Quality System in the Clinical Laboratory
Thursday, June 29, 2017
Ginger Weeden
Communication, collaboration, and thorough preparation are essential to developing a quality system. Read More
Product Contamination Visualization and Identification Using FTIR Microspectroscopy
Friday, September 29, 2017
David W. Schiering Anthony W. Didomenico John A. Seelenbinder
The identification of surface contamination particles on products is demonstrated using a new FTIR microspectroscopy accessory. Read More
Why Centrifugal Partition Chromatography is a Better Way to Extract Cannabidiol for Medical Research
Tuesday, September 05, 2017
Gregoire Audo
An alternative method for purifying cannabidiol and other cannabis extracts for research use is centrifugal partition chromatography Read More
Bioparticles, Molecules, and Complexes Analyzed by “Chromatography” Without a Stationary Phase
Friday, September 29, 2017
David M. Goodall Pawel L. Urban
Hydrodynamic chromatography (HDC) is a simple technique for separating particles of different size, from molecules to biological cells. Read More
Comparing the Stability of Protein Formulations
Friday, November 10, 2017
Michael Drenski
Because most therapeutic protein formulations are difficult and expensive to produce at high yields, biopharma companies need tools that provide rapid, high-quality protein stability information with ... Read More
A Field-Portable Bioanalysis System
Tuesday, July 11, 2017
Varouj Amirkhanian Eric Tsai Alice Lin
A portable bioanalysis system provides high resolution and high detection sensitivity, and is a cost-effective solution for the field detection of pathogens. Read More
Rethinking Ultrapure Water
Tuesday, September 05, 2017
Véronique Fontalbat
With an intelligently designed water purification system, each step of the ultrapure water workflow can be improved for great efficiency, ease of data management, and improved sustainability. Read More
An Effective Treatment Strategy for Cytokine Storm in Severe Influenza
Tuesday, July 25, 2017
Erin Murphy
Despite the use of vaccines and antiviral therapies such as oseltamivir, severe influenza kills thousands to tens of thousands of Americans each year. Read More
Next-Generation Software for Food and Forensic Laboratories
Friday, November 10, 2017
Phil Taylor
Food testing and forensic laboratories want to maximize productivity, deliver better-quality data, and remove the element of risk associated with manual interpretation, and the right software is ... Read More
Ion-Moderated Partitioning for Carbohydrate Analysis
Friday, September 29, 2017
Payal Khandelwal Mona Chin Anna Quinlan
This article discusses ion-moderated partitioning, a form of normal-phase HPLC for carbohydrate analysis that is often referred to as ion chromatography and is commonly used in the food and ... Read More
Best Practices for Circulating Baths When Measuring Viscosity Temperature Profiles
Friday, September 29, 2017
Robert G. McGregor
Best practices are given to ensure that bath performance meets the laboratory's needs for precise temperature control. Read More
Automated Nephelometric Turbidity Measurement of Biotherapeutics Formulations
Friday, September 29, 2017
Daniel Kinder
With accurate turbidity data, the Freeslate biologics formulation workstation provides rapid sample preparation and analysis to support drug discovery and development activities. Read More
Beyond the Limit: The World of Super-Resolution Microscopy
Friday, September 29, 2017
Russell Ulbrich
Scientists are using super-resolution microscopy to image living samples well beyond the established theoretical limit, allowing the study of far-ranging biological phenomena. Read More
Statistics in the Laboratory: The Minimum Consistently Detectable Amount
Tuesday, September 05, 2017
Stanley N. Deming
In the previous column we discussed the limit of detection LD, the minimum signal strength above which we can be confident that analyte is present, but with a small false positive risk a that analyte ... Read More
Optimized High-Throughput Compound Sample Management With An Acoustic Liquid Handling Platform
Monday, January 01, 2018
Isabella Broderick-Forster
Implementing a system centered around acoustic liquid handling helps bring the latest technology innovations to drug discovery and positively impacts all facets of sample management. Read More
Analysis of Benzene at Fence Lines Using GC/PID
Thursday, January 18, 2018
Jack Driscoll Jennifer Maclachlan
This article describes methods of preparing standards, materials used, and performance of a handheld portable gas chromatograph with a photoionization detector (GC/PID) for the analysis of ppb levels ... Read More
Analytical Technology on the Frontline of the War on Synthetic Cannabinoids
Friday, November 10, 2017
Dominic Andrada
Advances in LC/MS technology and cloud-based systems provide and new level of efficiency in forensics labs. Read More
Testing and Troubleshooting Liquid Chromatography Method Transfer
Friday, November 10, 2017
Paula Hong Jinchuan Yang Mark Benvenuti Gareth Cleland Patricia McConville
Factors that affect method transfer are discussed, particularly as they relate to the analysis of isoflavones in soy extract. Read More