Application Notes

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Quantitating VOCs in Serum Using Automated Headspace-SPME/Cryo-Focusing/Isotope Dilution/Capillary GC/MS
Friday, March 31, 2017
Paul R. Loconto
In January 2007, the author’s lab received a frozen shipment of calibration standards and quality control (QC) samples to perform method validation for quantitating traces of volatile organic ... Read More
How to Avoid Size Mismatch Between Solutes and Column Pores for Optimum HPLC Performance
Wednesday, June 07, 2017
Richard A. Henry Stephanie Schuster
This article describes a new approach for selecting optimum column pores for separating large molecules without losing high performance. Read More
Managing the Complexity of Microbial Biofuel Production With Integrated Informatics
Tuesday, May 09, 2017
Barbara van Cann
Integrated informatics solutions based on LIMS and chromatography data systems are helping biofuel producers ensure that processes are robust, safe and efficient. Read More
Using Raman Spectroscopy for Gemstone Analysis
Wednesday, June 07, 2017
Frank J. Yang Gerard Pereira Liang Don Chen
Raman spectroscopy is a nondestructive, extremely fast and low-cost option for gemstone analysis. Read More
Liquid Handling Uses Acoustic Droplet Ejection for Improved Results
Monday, May 08, 2017
Mark Fischer-Colbrie
Acoustic drop ejection systems can pave the way for entirely new applications, bringing higher throughput and greater flexibility to many areas of biology. Read More
Using Advanced Data-Management Solutions to Ensure Food Safety
Monday, May 08, 2017
Jeff Tishler Kevin Arnold
Accurate recording of research data and the ability to quickly search historical data and track the genealogy of products result in products being developed more rapidly and consistently while ... Read More
Determination of Calcium and Trace Metals in Clogged Biliary Endoprostheses Using ICP/MS
Wednesday, July 26, 2017
Heidi Fleischer Kerstin Thurow Mareike Warkentin Kinjal Ramani Sergej Bauer Detlef Behrend
This article describes a method used to determine calcium and trace metals using inductively coupled plasma/mass spectrometry (ICP/MS) to investigate the elementary composition of encrustations in ... Read More
Statistics in the Laboratory: The Limit of Detection
Wednesday, June 07, 2017
Stanley N. Deming
The phrase “limit of detection” sounds so simple, yet it leads to one of the biggest, murkiest, most frustrating swamps in the statistical literature. Read More
What Is Shear Rate and Why Is It Important?
Wednesday, June 07, 2017
David Moonay
Proper equipment selection may allow significantly different materials to be tested with one machine and geometry, merely by changing the testing speed or shear rate. Read More
A Real-Time Concentration Monitor for Flowing Streams
Wednesday, July 26, 2017
Gary W. Yanik Necmi Bugdayci Soydan Kavraal
A real-time concentration monitor will improve the benefits of continuous processing and analysis by reducing or eliminating the need for sample extractions and off-line analyses. Read More
Particulate Analysis of Liquid Filtration Materials and Residues in Food Using FTIR Microscopy
Thursday, June 01, 2017
Michael Bradley Steve Lowry
Two sets of analyses are presented—one involving liquid filtration and the other examining particulate residues in food items—using a simple-to-operate FTIR microscope and attenuated total reflection ... Read More
Quantitation Without Calibration—Eliminating the Requirement for Calibration Curves in the GC-FID Analysis of Ethanol in Blood, Urine, and Serum
Wednesday, July 26, 2017
Charlie Spanjers Gregory C. Janis
A catalytic microreactor and flame ionization detector enabled accurate analytical quantitation without the analytical overhead or potential inaccuracy associated with the use of a calibration curve. Read More
Automated Glucose Control
Tuesday, September 05, 2017
Stuart Tindal Sebastian Ruhl Diana Dreiling
A bioreactor control system was used for glucose feed control. Read More
Manufacturing Considerations for IVD Reagents Used in Clinical Chemistry and Special Chemistry Laboratories
Tuesday, July 25, 2017
Robert J. Janetschek Julia Nisbet-Fahy Andrew Whitehouse
To produce diagnostic reagents that meet current and future demands requires a knowledge, understanding, and appreciation of the various reagents used for clinical testing applications. Read More
A New Era in Filtered Fume Enclosure Safety
Wednesday, June 07, 2017

The latest ductless filtered fume enclosures are a vital resource in the safe and effective operation of modern industrial, educational, hospital, forensic, and pharmaceutical scientific laboratories. Read More
Top-Down Proteomics: An Emerging Technology Propelled by Mass Spectrometry
Wednesday, July 26, 2017
Rohan A. Thakur
Rapid developments in mass spectrometry technology facilitate innovative solutions to the challenges in top-down proteomics. Read More
Long-Range Genomics Is Reviving a Lost Art
Wednesday, July 26, 2017
Chris Boles
The instrument described here was designed to treat DNA gently enough that users can prepare libraries of extremely large fragments directly from blood samples, bacterial and tissue cultures, or other... Read More
Fume Hoods and Cabinets
Friday, May 19, 2017

Biological safety cabinets and fume hoods protect samples, personnel and the laboratory environment from harsh chemicals or infectious substances. Read More
Choosing a LIMS: Configuration vs Customization
Thursday, September 28, 2017
Simon Wood
When choosing a LIMS, users should consider two distinct methodologies: configuration and customization. Read More
A Virtual Instrument System for Testing the Validity of Drugs
Monday, September 04, 2017
Xun Gong Wen Wu Qijun Wu Cheng Cai
A virtual instrument system for measuring the validity period of drugs enhances the performance of spectrophotometers. Read More