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The Role of Analytical Instrumentation in the Life Sciences
Saturday, November 01, 2008
Robert L. Stevenson, Ph.D. C. David Carr
Historically, the life sciences have been qualitative in nature, seeking to identify but seldom understand quantitatively. read more
A Device for Isoelectric Focusing of IPG Gel Strips
Tuesday, November 18, 2008
Nancy Laird Jeff Cohen John Attwood
For more than 30 years, 2-D electrophoresis has been used by researchers around the globe to separate proteins by charge and then by size. read more
The Helium Ion Microscope: The Next Stage in Nanoscale Imaging
Monday, November 24, 2008
Larry Scipioni Mohan Ananth John Notte
The helium ion microscope is being proven to offer solutions for imaging at the nanoscale. read more
High-Throughput Cell Cycle Analysis Using a Microplate Cytometer
Friday, November 28, 2008
Paul Wylie
The traditional method of determining the cell cycle phase of individual cells is by quantifying their total DNA content using flow cytometry. read more
Improving the Laboratory Work Experience When Homogenizing
Friday, November 28, 2008
Karl Jahn
It is no secret to researchers who homogenize tissue samples as part of their regular laboratory routine that the job can be messy and loud, and produce results that are sometimes inconsistent. read more
What is “Hot” in Column Technologies for Liquid Chromatography?
Thursday, December 04, 2008
Frantisek Svec
It has been just over 100 years since Russian botanist Mikhail Semionovich Tswett invented the separation technique that he named chromatography. read more
Making Single-Molecule Sequencing a Reality
Friday, December 05, 2008
Avak Kahvejian Steve Kellett
The quest to directly sequence individual strands of DNA has challenged genomic technologists for decades. read more
Desktop Biological Nanopatterning Using Dip-Pen Nanolithography
Friday, December 05, 2008
Jason Haaheim Omkar A. Nafday
The ability to control the size and shape of deposited chemical structures on the nanoscale opens up new and exciting possibilities for the development of devices for use in the electronic, life ... read more
An Immunoaffinity Capillary Electrophoresis Biomarker Analyzer for Use in Toxicoproteomics Research
Friday, December 05, 2008
Norberto A. Guzman
The slow pace of discovery of new protein biomarkers of toxicity or “toxicity signature protein/peptides” is partially due to the lack of high-throughput and high-sensitivity biomarker devices. read more
WS-CRDS: Precision Trace Gas Analysis and Simplified Stable Isotope Measurements
Friday, December 05, 2008
Eric R. Crosson
Wavelength-scanned cavity ring-down spectroscopy (WSCRDS) is fast gaining worldwide acceptance as a superior tool for trace gas analysis, because it combines operational simplicity and portability ... read more
Statistics in Analytical Chemistry: Part 32—Detection Limits Via 3-Sigma
Friday, December 05, 2008
David Coleman Lynn Vanatta
As was mentioned in the first article on detection limits (DLs) (Part 26, American Laboratory, June/July 2007), many formulas exist for calculating these values. read more
Achieving Consistency and Reproducibility in Cell-Based Research
Friday, December 05, 2008
Jeff Goldman
In recent years, advances in mammalian cell-based research have enabled many scientific and medical discoveries. read more
Detecting the Future of Bioscience
Saturday, December 13, 2008
Gabriella Armin
The potential to use antibodies as research tools has been known since the early 1890s, when Karl Landsteiner used antibodies to distinguish between the ortho and meta configurations of groups on ... read more
Identifying Pharmaceuticals in Surface Water Using LC-MS/MS in Both Positive and Negative Ion Modes
Thursday, January 01, 2009
Chin-Kai Meng
Compounds such as antibiotics, over-the- counter medicines, and caffeine drain through the sewage system largely unaltered into rivers and streams, and even enter the drinking water supply in very ... read more
An Upgradeable FTIR Accessory for Microscopy and Imaging Applications
Friday, January 23, 2009
Ken-ichi Akao Richard A. Larsen Jun Koshoubu
FTIR microscope systems allow the analysis of extremely small samples (<250 µm) using infrared spectroscopy. Mapping experiments utilizing a single-element detector can provide infrared image data ... read more
Using Light Scattering to Characterize SiO2 Chemical Mechanical Planarization Slurries
Sunday, February 01, 2009
Hui Ning
Chemical mechanical planarization (CMP) slurries are typically colloidal dispersions of silicon dioxide (SiO2) in an acid or base solution. They are integral to the semiconductor industry, emerging as... read more
Solutions for Global Health and Well-Being
Sunday, February 01, 2009
Sandra Rasmussen
From investigating mercury-laden tuna sushi in Manhattan to high-profile recalls of contaminated toys and international concern over the quality of water and air in the 2008 Olympic Village, meeting ... read more
Fish-Related Standard Reference Materials
Sunday, February 01, 2009
Michele Schantz Stephen A. Wise Steven J. Christopher W. Clay Davis Rusty D. Day Jennifer M. Keller John R. Kucklick Stephen E. Long Elizabeth A. Mackey David Point Barbara J. Porter Dianne L. Poster Katherine E. Sharpless Gregory C. Turk
Humans have been eating fish for thousands of years, enjoying its nutritional benefits. In extreme cases, health risks posed by contaminants can outweigh the health benefits imparted by fish ... read more
Simply Intelligent: A Next-Generation Chromatography Data System
Thursday, February 26, 2009
James A. Schibler Fraser McLeod
Chromatography data systems perform many complex tasks, including instrument control, data capture, qualitative and quantitative data analysis, and report generation. To perform these tasks ... read more
Sub-2-Micron Performance With a Conventional HPLC Instrument Using 2.7-Micron Fused Core Particles
Friday, March 20, 2009
Thomas L. Chester
Ultrahigh-performance liquid chromatography (UHPLC) utilizes sub-2-µm-diam stationary phase particles to provide improved performance over conventional HPLC. This can be realized either in a higher ... read more