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Key Requirement Differences for Electronic Notebooks in Discovery, Development Research, and cGMP Manufacturing Environments
Friday, March 20, 2009
John P. Helfrich
Many leading life science companies have cost reduction initiatives to eliminate the routine, nonvalueadded tasks through automation. In most regulated companies, approximately 70% of laboratory-based...
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Statistics in Analytical Chemistry: Part 33—Detection Limits via 3-Sigma (Concluded)
Friday, March 20, 2009
David Coleman
Lynn Vanatta
In the last installment (Part 32, American Laboratory, Nov/Dec 2008) of this series, three detection limits (DLs) were calculated (via the 3-Sigma [3s] approach, where a is set to be 0.01) for a ...
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Focus on Microscopy: One Button and Two Heads—Mainstreaming AFM
Friday, April 17, 2009
Barbara Foster
The past decade has seen dramatic growth in scanning probe microscopy (SPM) technology, both in functionality and in broader acceptance. Market research conducted in mid-2007 by The Microscopy and ...
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Comparison of Methyl Benzoate and Ergosterol for the Quantification of Mold in Indoor Buildings and Materials
Friday, April 17, 2009
Don-Roger Parkinson
Over the last few years there have been many school and business closures related to mold and bacteria buildup, which have affected the health of the occupants. Mold growth has been potentially linked...
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A Weak Cation-Exchange, Reversed-Phase Mixed-Mode HPLC Column and its Applications
Friday, April 17, 2009
Xiaodong Liu
Christopher Pohl
Basic compounds are widely used in many areas, such as pharmaceutical development, biological research, consumer products, and in the chemical industry. Although reversed-phase (RP) liquid ...
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Antifungal, Insecticidal, Cytotoxicity, and Phytotoxicity Studies of Binuclear Ni(II) and Cu(II) Complexes of Diclofenac
Thursday, May 28, 2009
Muhammad Farid Khan
Fazal-Ur- Rehman
Gul Majid Khan
Inamullah Khan
Farooq Ibad
Diclofenac, a nonsteroidal antiinflammatory drug (NSAID), is one of the most frequently used medicines for the treatment and management of pain and edema associated with rheumatoid arthritis, ...
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Statistics in Analytical Chemistry: Part 34—Detection-Limit Summary
Thursday, May 28, 2009
David Coleman
Lynn Vanatta
The subject of detection limits (DLs) is a controversial one, generating many questions and almost endless debate.
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High-Throughput Screening Applications for Enantiomeric Excess Determination Using ESI-MS
Thursday, June 18, 2009
Heidi Fleischer
Dirk Gördes
Kerstin Thurow
In the past decades, high-throughput screening (HTS) applications have been established in many fields of drug development. Thus, suitable qualitative and quantitative analytical methods have become ...
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Prediction of NOx Emissions in Boilers Using Neural Networks and Excel™
Thursday, June 18, 2009
Enrique Arce-Medina
In an attempt to demystify artificial neural networks (ANNs) and to set the tone of this paper, it is best to start by saying that ANNs are mathematical functions of the form y = f(x, w), where y is ...
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Automated, Economical Sample Preparation: Bottle Liquid–Liquid Extraction
Wednesday, July 01, 2009
John R. Troost
The extraction of organics from water is fundamental in environmental, pharmaceutical, process, food, forensic, and other laboratories. Nearly all laboratories that perform organic analyses are ...
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Determination of Nitrobenzene in Water Using Ionic Liquid-Based Liquid-Phase Microextraction Coupled With HPLC
Wednesday, July 01, 2009
Dongmei Cha
Bin Ma
Nitrobenzene is widely used as an intermediary in the chemical industry. The release of nitrobenzene into the environment is of great concern because of its toxicity, persistence, and accumulation ...
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Use of a Compact, High-Purity Water System in a Rockville, Maryland, Forensics Laboratory
Wednesday, July 22, 2009
Trude Witham
When the Montgomery County Crime Laboratory in Rockville, MD, needed a high-purity water system for a new laboratory area, a compact system that would supply Type I water from tap-water feed was ...
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Dynamic Mechanical Analysis Under Controlled Conditions of Temperature and Relative Humidity
Saturday, August 01, 2009
Steven R. Aubuchon
Historically, dynamic mechanical analysis (DMA) measurements have focused on the analysis of materials as a function of an imposed temperature profile. However, most consumer products are subject to a...
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New Developments in Weighing Technology That Meet the Needs of Advanced Pharmaceutical and Manufacturing Compliance Protocols
Saturday, August 01, 2009
Arnold Breisblatt
One of the worst-case scenarios for a pharmaceutical laboratory is to have a government inspector close down the facility because it cannot provide regulatory compliance documentation, much less ...
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A High-Performance, Fully Self-Contained, Rotational Viscometer
Saturday, August 01, 2009
Tien T. Dao
Allan X. Ye
Gary Hutchison
Kaj Hedman
Routine viscosity measurements of materials are important in most industrial processes such as mixing and pumping, spraying and coating, extrusion, laydown, and leveling. Typically, a rotational ...
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Validating Process and Action Limits for Automated Liquid Handlers in Volume-Dependent Assays
Wednesday, August 19, 2009
Keith Volk
Errors in automated liquid handling can have a significant impact on data integrity. Since automated liquid handling is a relatively new and rapidly advancing technology, standardized verification ...
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Statistics in Analytical Chemistry: Part 35—Reporting Data and Significant Digits
Thursday, August 20, 2009
David Coleman
Lynn Vanatta
"In almost all cases when dealing with a limit of detection or limit of determination, the primary purpose of determining that limit is to stay away from it.”
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A Promise Kept: Stem Cells Key to Life-Saving Operation
Wednesday, August 26, 2009
John Meech
Prof. Anthony Hollander had always believed that he would be able to save lives. He believed it so strongly, in fact, that he wrote to a television program as a child asking for a few tools to help ...
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Use of an Analytical Balance for Sensitive Weighing Tasks
Wednesday, August 26, 2009
Marie-Louise Hupert
The independent Forensic Scientific Service (FND) of the State Police in St. Gallen, Switzerland conducts analytical and forensic tests with the aim of detecting proof of suspected crimes such as the ...
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Extracting Greater Value From Scientific Data: An Optimized Approach
Tuesday, September 01, 2009
Frank Brown
Today’s pharmaceutical, chemicals, materials, and consumer packaged goods (CPG) organizations must deal with a number of competing challenges: From a business perspective, they face growing pressures ...
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