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LC-MS With Simultaneous Electrospray and Atmospheric Pressure Chemical Ionization
Tuesday, March 01, 2005
Wayne P. Duncan Patrick D. Perkins
Today, liquid chromatography-mass spectrometry with electrospray ionization (LC-ESI-MS) is increasingly being used as the technique of choice for high-throughput pharmaceutical analysis. read more
Multicapillary Columns for Chromatography
Tuesday, March 01, 2005
Yuri P. Belov Marina M. Ulyanova Vladimir N. Sidelnikov
The principles and theory of high-speed capillary chromatography have been known since the 1960s. To realize the maximum speed capabilities, it is necessary to use capillaries with a diameter of ... read more
Determination of Acid Herbicides in Water by GC-MS: A Modified Method Using Single Extraction and Methanol Esterification
Tuesday, March 01, 2005
Pradyot Patnaik Jacques N. Khoury
Chlorophenoxy acids are an important class of herbicides that are widely used for weed control in agriculture and forestry. read more
Analytical Method Execution Automation: PAT for Pharmaceutical QC Laboratory Operations
Friday, March 25, 2005
John P. Helfrich
With the FDA’s increasing focus on modernizing regulation of pharmaceutical manufacturing and product quality, companies are being forced to reexamine whether traditional development and ... read more
Global Strategy for Data Management in the QC Laboratory
Friday, March 25, 2005
Joseph A Hofmann, Jr.
The quality control (QC) unit of any global supply chain for a large corporate entity is responsible for the testing of products and materials across all manufacturing sites within the supply chain, ... read more
Whole Genome Amplification: Extending Beyond the Limitations of Traditional PCR
Monday, April 04, 2005
Alicia Pruett Tony Favello Ernie Mueller
The history of molecular biology is marked by technological advances that have opened up the investigation of both fundamental and applied biological problems. read more
Freeze-Drying 101: Lyophilization Technology
Monday, April 04, 2005
Charles D. Dern
Freeze-drying is a complex and not completely understood process that requires one to carefully balance product requirements with equipment capabilities. read more
Focus on Microscopy: AFM’s New Nanotomography Expands 3-D Imaging
Sunday, May 01, 2005
Barbara Foster
Atomic force microscopy (AFM) is well known for its ability to image and measure surface properties. read more
Statistics in Analytical Chemistry: Part 16—Calibration Example 5 (Concluded)
Sunday, May 01, 2005
David Coleman Lynn Vanatta
In the previous article (American Laboratory, Feb 2005), calibration data were diagnosed for a study involving phosphate. read more
Capillary-Channeled Polymer (C-CP) Fibers: A Novel Platform for Liquid-Phase Separations
Wednesday, June 01, 2005
Dwella M. Nelson Rayman D. Stanelle Phil Brown R. Kenneth Marcus
In spite of its relative maturity as a group of analytical methods, the field of liquid chromatography continues to evolve with regard to the development of new stationary phases that may provide ... read more
Using FAIMS to Increase Selectivity for LC-MS Analyses
Wednesday, June 01, 2005
Roger Guevremont Beata Kolakowski
In the development of many LC-MS methods, interferences are commonplace. In an environment in which data must stand up to rigorous scrutiny, such as in the pharmaceutical industry, selectivity of ... read more
Nitro Musk Adducts of Rainbow Trout Hemoglobin: Dose–Response and Toxicokinetics Determination by GC-NICI-MS for a Sentinel Species
Wednesday, June 01, 2005
Mohammad A. Mottaleb William C. Brumley Lawrence R. Curtis G. Wayne Sovocool
Rainbow trout and other fish species can serve as “sentinel” species for the assessment of ecological status and the presence of certain environmental contaminants. As such, they act as ... read more
Microscopy is Moving On
Friday, July 01, 2005
Aubrey Lambert
The basis for observations has not really changed in all the time that lenses have been used to magnify objects. read more
Methodologies for Stabilization of Pharmaceuticals in Biological Samples
Friday, July 01, 2005
Jiwen Chen Ganfeng Wang Jean-Marc Brisson Yunsheng Hsieh
The instability of small drug molecules in biological fluids causes serious bioanalytical challenges, regardless of what type of powerful analytical technology is employed for the bioanalytical ... read more
Statistics in Analytical Chemistry: Part 17—Calibration Example 6
Monday, August 01, 2005
David Coleman Lynn Vanatta
This installment will present the sixth and last in this series of calibration examples. read more
Statistics in Analytical Chemistry: Part 18—Calibration Example 6 (Concluded)
Thursday, September 01, 2005
David Coleman Lynn Vanatta
In the previous article (American Laboratory Aug 2005), borate data were presented. No single model was found to be adequate. read more
How to Minimize Septum Problems in GC
Thursday, September 01, 2005
Jaap de Zeeuw
Although GC has been in use for more than three decades, the simple solution of sealing a hot, pressurized injection system with a slice of silicone is still being practiced. read more
A Novel Chemical Route to Stable, Regenerable Zirconia-Based Chiral Stationary Phases for HPLC
Saturday, October 01, 2005
Richard A. Henry Clayton V. McNeff Bingwen Yan Thomas R. Hoye
High-performance liquid chromatography has become the dominant method for the analytical and preparative separation of chiral pharmaceuticals. read more
Subcellular Protein Localization With High Resolution: The Next Step in Proteomics
Monday, October 03, 2005
Jack Elands Hong Yi Jan L.M. Leunissen
Genomics and proteomics have determined the molecular sequences and structures of a large number of proteins. read more
Focus on Microscopy: Spectroscopy + Microscopy + . . .? What’s Next?
Tuesday, November 01, 2005
Barbara Foster
Thomas Friedman, author of the recent book, The World is Flat, identified convergence of technologies as a key driving force shaping today’s world. read more