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2-D NMR Developments Improve Monoclonal Antibody Characterization
Ten years ago, industry commentators noted the increasing importance of biologics, and monoclonal antibodies (mAbs), in particular.
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High-Throughput Drug Screening of Multicellular Tumor Spheroids
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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Cancer Throws Another Curveball
Metastasis of solid cancer tumors is a crucial step in progression and generally portends poor patient outcome.
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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Ten Tips for Proper Pipetting
Pipetting proficiency is one of the most critical elements to ensure accuracy and precision, particularly in the face of high personnel turnover, growing laboratory workloads and increasingly complex ...
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Achieving Accuracy and Reproducibility With Electronic Pipettes
Researchers are continuously seeking ways to improve efficiency while ensuring that their methods are reliable and their research is reproducible.
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For Accurate Cell-Based Assay Results, Transfer Technique Matters
From smaller-scale assays to industrial-scale screening operations, cell-based assays are critical for applications that include elucidating basic mechanisms of cell function, target validation and ...
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NGS Library Validation Using Automated Capillary Gel Electrophoresis
Next-generation sequencing (NGS) is widely used in genomics, epigenetics and transcriptomics, etc., and also in such clinical diagnostics applications as cancer screening and drug development.
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siRNA Knockdown: Implementing Negative Controls in Antibody QC
This article presents an overview of short interfering RNA (siRNA) knockdown, a powerful negative control method, followed by tips to optimize siRNA transfection experiments.
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Comparison of ICP-QQQ and MP-AES to Alternative Atomic Spectroscopy Techniques
This article gives an overview of the various atomic spectroscopy techniques available to address a range of applications in environmental science, food and agriculture, life sciences and academic ...
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Refrigeration Practices for Biological Sample Preservation
Preservation of biological samples such as tissues, plasma and forensic and pathology specimens relies on maintaining proper storage temperatures and on the type of sample and analysis to be done. ...
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Super-Resolution Microscopy Techniques Combine to Clarify Spatiotemporal Structure of the Endoplasmic Reticulum
Super-resolution microscopy encompasses several new techniques for direct spatiotemporal imaging of structural features much smaller than the diffraction limit of light. The endoplasmic reticulum (ER)...
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Individual Cell Analysis for Protein Expression and Cell Health Markers
The Muse instrument uses microcapillary fluidics and preoptimized reagents to create an inexpensive, compact, portable cell analyzer that requires minimal setup and no expertise to operate.
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LASE With Nano-Lasers
Want to improve contrast and definition in super-resolution imaging, especially in the z-axis? A report by Sangyeon Cho and colleagues at Harvard Medical School shows that nano-lasers are a clever new...
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Tomography for Super-Resolution 3-D and 4-D Imaging
Compared to 2-D techniques, tomographic technology provides 3-D images with improved resolution in the z-axis.
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