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A Matter of Speed: Real-Time PCR for the Rapid Detection of Mycoplasma Contamination
Wednesday, June 11, 2014
Mycoplasma are among the world’s smallest bacteria capable of independent reproduction. They belong to the class of Mollicutes and have a very slow and parasitic growth.
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Book Review: The Physics of the Future
Thursday, May 22, 2014
During the last year, I’ve been attracted to books describing paradigm shifts enabled by today’s new technology, particularly big data and IT—hence my interest in books from visionaries, which might ...
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Driving Scientific Innovation: Managing Biologics R&D Data Effectively
Monday, May 19, 2014
Over the past decade, the biological laboratory has become an increasingly digitally enhanced place. These days a skills section of a CV is more likely to include various instruments and software ...
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Meeting the Challenge of Biological Changes Postsampling
Friday, May 16, 2014
Understanding the role of proteins, peptides, and their post-translational modifications, e.g., phosphorylations, in normal and diseased biological samples is crucial to elucidate in vivo biological ...
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Quality Control: An Important Success Factor in Nucleic Acid-Based Analysis
Tuesday, April 01, 2014
Quality control (QC) is becoming increasingly important in nucleic acid-based testing. As detection technologies become more and more sensitive, final results are influenced not only by biological ...
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Single-Cell RNA Detection to Identify Cell Subpopulations in Heterogeneous Mixtures
Tuesday, March 25, 2014
Traditional RNA detection methods, which analyze RNA levels in lysed, permeabilized, or fixed cell samples, make it challenging to understand the role of one gene in the context of a tissue, organ, or...
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LIMS-BPMS Coupling: A Novel Approach for Flexible End-to-End Workflow Automation in Life Science Laboratories, Part 1
Tuesday, March 11, 2014
Generalized life science automation (LSA) includes all application areas of laboratory automation, i.e., health care, pharmaceutical development, chemistry, and biology. The connection of all ...
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The Scales of Scientific Justice in Translational Science: Data Reproducibility and Verifiable Science
Tuesday, March 04, 2014
The traditional “scales of justice” represent truth and fairness. For the scientific community, the balance is between big data (terabytes of data across numerous databases) on one scale and ...
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Improved Pipetting Technique: An “Out-of-the-Box” Solution to Reduce Manual Pipetting Errors
Monday, March 03, 2014
Handheld air-displacement pipets are used in virtually every laboratory around the world. The technique and skills of individual pipet operators are critical to the accuracy of results of liquid ...
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Electronic Pipetting: The Call for Innovation
Thursday, February 27, 2014
Take a close look around most laboratories and you will find an old, barely used fixture. No one knows who ordered it or who it belongs to. It is yellowed, dusty, and top heavy, with a small keyboard ...
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Automated Colony Counting: A Critical Requirement for Advanced Cancer Research
Monday, February 10, 2014
The colony counting method has long been recognized as the primary method for measuring the effects of radiation, chemotherapeutic drugs, and other agents on cell viability.
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Seeing Molecular Interactions of Large Complexes by Cryo Electron Microscopy at Atomic Resolution
Thursday, February 06, 2014
Suppose one has never seen an automobile and is asked to perform the simple task—while blindfolded—of adding gasoline to the car and checking its oil. A task like this is impossible to perform until ...
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The MIQE Bedtime Story: A Tale of Two qPCR Experiments
Friday, January 31, 2014
Kelly and Ted were two budding Ph.D. students from different labs in fierce competition and required the use of qPCR (quantitative PCR) to support results generated from microarray and systems biology...
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Identification of Cancer Stem Cells Within Mixed Populations Using Live Cell RNA Detection
Thursday, January 09, 2014
Despite the ubiquity of studies measuring mRNA and miRNA levels, many current techniques require cell lysis and are enormously disruptive to the cells being studied.
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The 10 Most Significant Questions to Consider When Planning a Sample Management System
Wednesday, December 18, 2013
On the surface, sample management does not appear to be so complex—after all, it isn’t rocket science, right? In reality, though, there is a huge diversity in sample management requirements (...
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