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Title
Three-Dimensional Co-Culture More Closely Mimics in vivo Interactions of Breast Cancer to Aid Drug Discovery
Wednesday, July 26, 2017
Lubna Hussain
Ying Nie
Krista Garner
Human mammary epithelial cells and human mammary fibroblasts can be successfully grown in a 3-D co-culture system to mimic the heterotypic interactions of breast cancer cells and stromal cells in vivo...
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A Real-Time Concentration Monitor for Flowing Streams
Wednesday, July 26, 2017
Gary W. Yanik
Necmi Bugdayci
Soydan Kavraal
A real-time concentration monitor will improve the benefits of continuous processing and analysis by reducing or eliminating the need for sample extractions and off-line analyses.
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Determination of Calcium and Trace Metals in Clogged Biliary Endoprostheses Using ICP/MS
Wednesday, July 26, 2017
Heidi Fleischer
Kerstin Thurow
Mareike Warkentin
Kinjal Ramani
Sergej Bauer
Detlef Behrend
This article describes a method used to determine calcium and trace metals using inductively coupled plasma/mass spectrometry (ICP/MS) to investigate the elementary composition of encrustations in ...
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Top-Down Proteomics: An Emerging Technology Propelled by Mass Spectrometry
Wednesday, July 26, 2017
Rohan A. Thakur
Rapid developments in mass spectrometry technology facilitate innovative solutions to the challenges in top-down proteomics.
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Long-Range Genomics Is Reviving a Lost Art
Wednesday, July 26, 2017
Chris Boles
The instrument described here was designed to treat DNA gently enough that users can prepare libraries of extremely large fragments directly from blood samples, bacterial and tissue cultures, or other...
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Quantitation Without Calibration—Eliminating the Requirement for Calibration Curves in the GC-FID Analysis of Ethanol in Blood, Urine, and Serum
Wednesday, July 26, 2017
Charlie Spanjers
Gregory C. Janis
A catalytic microreactor and flame ionization detector enabled accurate analytical quantitation without the analytical overhead or potential inaccuracy associated with the use of a calibration curve.
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A Virtual Instrument System for Testing the Validity of Drugs
Monday, September 04, 2017
Xun Gong
Wen Wu
Qijun Wu
Cheng Cai
A virtual instrument system for measuring the validity period of drugs enhances the performance of spectrophotometers.
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Why Centrifugal Partition Chromatography is a Better Way to Extract Cannabidiol for Medical Research
Tuesday, September 05, 2017
Gregoire Audo
An alternative method for purifying cannabidiol and other cannabis extracts for research use is centrifugal partition chromatography
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Rethinking Ultrapure Water
Tuesday, September 05, 2017
Véronique Fontalbat
With an intelligently designed water purification system, each step of the ultrapure water workflow can be improved for great efficiency, ease of data management, and improved sustainability.
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Statistics in the Laboratory: The Minimum Consistently Detectable Amount
Tuesday, September 05, 2017
Stanley N. Deming
In the previous column we discussed the limit of detection LD, the minimum signal strength above which we can be confident that analyte is present, but with a small false positive risk a that analyte ...
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Automated Glucose Control
Tuesday, September 05, 2017
Stuart Tindal
Sebastian Ruhl
Diana Dreiling
A bioreactor control system was used for glucose feed control.
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Choosing a LIMS: Configuration vs Customization
Thursday, September 28, 2017
Simon Wood
When choosing a LIMS, users should consider two distinct methodologies: configuration and customization.
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Bioparticles, Molecules, and Complexes Analyzed by “Chromatography” Without a Stationary Phase
Friday, September 29, 2017
David M. Goodall
Pawel L. Urban
Hydrodynamic chromatography (HDC) is a simple technique for separating particles of different size, from molecules to biological cells.
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Product Contamination Visualization and Identification Using FTIR Microspectroscopy
Friday, September 29, 2017
David W. Schiering
Anthony W. Didomenico
John A. Seelenbinder
The identification of surface contamination particles on products is demonstrated using a new FTIR microspectroscopy accessory.
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Ion-Moderated Partitioning for Carbohydrate Analysis
Friday, September 29, 2017
Payal Khandelwal
Mona Chin
Anna Quinlan
This article discusses ion-moderated partitioning, a form of normal-phase HPLC for carbohydrate analysis that is often referred to as ion chromatography and is commonly used in the food and ...
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Best Practices for Circulating Baths When Measuring Viscosity Temperature Profiles
Friday, September 29, 2017
Robert G. McGregor
Best practices are given to ensure that bath performance meets the laboratory's needs for precise temperature control.
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Automated Nephelometric Turbidity Measurement of Biotherapeutics Formulations
Friday, September 29, 2017
Daniel Kinder
With accurate turbidity data, the Freeslate biologics formulation workstation provides rapid sample preparation and analysis to support drug discovery and development activities.
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Beyond the Limit: The World of Super-Resolution Microscopy
Friday, September 29, 2017
Russell Ulbrich
Scientists are using super-resolution microscopy to image living samples well beyond the established theoretical limit, allowing the study of far-ranging biological phenomena.
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Isothermal Titration Calorimetry: An Indispensable Tool for Biological Pathway Research and Drug Development
Monday, October 02, 2017
Verna Frasca
As our knowledge of the genetic and molecular basis of disease continues to grow, drug development programs focus increasingly on those proteins associated with disease states.
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ASTM-Approved Method for Simultaneous Determination of Total Nitrogen and Phosphorus in Wastewater by Ion Chromatography
Monday, October 02, 2017
Jeff Rohrer
Richard Jack
Brian De Borba
As natural elements in aquatic ecosystems, nitrogen and phosphorus support the growth of algae and aquatic plants, providing food and shelter for fish and other organisms.
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