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Title
High-Throughput Drug Screening of Multicellular Tumor Spheroids
Tuesday, September 27, 2016
Ana Maria P. Pardo
Hannah J. Gitschier
David H. Randle
Terry Riss
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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High-Throughput Screening of Multiple Protein Complexes
Thursday, July 04, 2013
Imre Berger
Maxime Chaillet
Frederic Garzoni
Sinyee Yau-Rose
Barney Zoro
Key protein complexes are fundamental to a wide range of cellular processes and key metabolic pathways within the body. Their dysfunction is associated with a range of disease pathologies such as ...
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High-Throughput Tools for Optimizing Drug Nanosuspensions
Thursday, February 19, 2015
Dennis H. Leung
Timothy Rhodes
Annette Bak
Inadequate absorption and bioavailability often make it difficult to deliver the drug to the target in vivo and pose significant challenges to the discovery and development of new drugs. A number of ...
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High-Throughput VOC and Inorganic Gas Analysis: Automated SIFT-MS
Friday, January 20, 2017
Mark J. Perkins
Vaughan S. Langford
Murray J. McEwan
A sensitive technique called selected ion flow tube mass spectrometry (SIFT-MS) allows the direct, real-time monitoring of inorganic gases and volatile organic compounds (VOCs), with no need to ...
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How Do You Evaluate “Flowability”? Buttermilk Ranch vs Blue Cheese
Monday, November 24, 2014
Robert G. McGregor
Eric Chiang
Stephanie Shepard
A common request from food manufacturers is to come up with a faster and more definitive test for flowability of salad dressings.
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How Electronic Laboratory Notebooks Aid in the Development of Bioanalytical Assays for Large Molecule Detection by LC/MS
Wednesday, April 16, 2014
Laura Swift
The use of electronic laboratory notebooks (ELNs) is becoming more popular among research and development (R&D) organizations. These electronic platforms optimize workflow and expedite data analysis ...
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How Lab Informatics Technologies Help Meet Evolving Healthcare Needs
Wednesday, February 05, 2014
Shooki Grasiani
Don Koch
Randy Hice
As U.S. healthcare providers (HCPs) navigate a changing healthcare climate, diagnostic laboratories are playing an increasingly important role in helping them prevent medical errors, lower ...
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How Pierced PTFE/Silicone Septa Affect GC-MS Experiments
Monday, January 02, 2006
Yanxiang Wang
The analysis of a sample generally involves a series of steps in which glassware and other sample processing hardware are used.
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How Solid-Phase Extraction Affects Challenges in Bioanalysis
Wednesday, February 05, 2014
Mike Oliver
Tim Liddicoat
Ken Meadows
Modern bioanalytical laboratories are tasked with providing high-quality analytical results from complex biological samples in a high-throughput environment. These needs have to be balanced with the ...
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How to Avoid Size Mismatch Between Solutes and Column Pores for Optimum HPLC Performance
Wednesday, June 07, 2017
Richard A. Henry
Stephanie Schuster
This article describes a new approach for selecting optimum column pores for separating large molecules without losing high performance.
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How to Choose Between a CCD and sCMOS Scientific-Grade Camera
Wednesday, April 29, 2015
James Joubert
Cell biologists require microscopy tools that can detect rapid movements within a cell with detail and sensitivity in low light conditions. Developers must address performance requirements, and be ...
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How to Choose the Right Liquid Handling Automation Platform
Friday, January 11, 2019
Hal Wehrenberg
This article discusses some of the key points to consider when choosing a liquid handling platform for your laboratory.
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How to Select the Best siRNA Transfection Reagent
Wednesday, June 05, 2013
Josh P. Roberts
The choice of a transfection reagent for small, interfering RNAs, or siRNAs, is largely dependent on the type of cell and species and the downstream assay. According to this guide, the two most ...
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How Visualization and Analytics Help Scientists Make Better Decisions Faster
Friday, May 11, 2018
Tom Oldfield
Robert D. Brown
Artificial intelligence. Machine learning. Automation. As these technologies become more widely adopted among life sciences companies in hopes of better innovation and faster drug development, it is ...
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HPLC Application Note: U.S. EPA Priority Pollutants in Water
Friday, February 18, 2011
Cecil Instruments Ltd.
Most basic recommended instrument: Cecil Adept System 4S.
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HPLC Application Note: Ultralow Detection Limits for Inorganic Anions and Cations in Power Station Boiler Water Analysis
Friday, February 18, 2011
Cecil Instruments Ltd.
Boilers used in power stations hold ultrapure water, and the purity of that water must be determined by highly sensitive techniques.
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ICP Spectrometry Coupled With a Separate Sampling and Excitation Accessory for Rapid Analysis of Impurities in Silver
Wednesday, July 01, 2009
George Buchbinder
Nikolai Verblyudov
Andrew Clavering
Silver is one of the oldest metals known to humanity and is still very important in minting, jewelry, and industry. Silver can be obtained from pure deposits and ores and, like other precious metals, ...
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Identification of Cancer Stem Cells Within Mixed Populations Using Live Cell RNA Detection
Thursday, January 09, 2014
Don Weldon
Steve McClellan
Despite the ubiquity of studies measuring mRNA and miRNA levels, many current techniques require cell lysis and are enormously disruptive to the cells being studied.
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Identification of Microplastics in the Marine Environment by Raman Microspectroscopy and Imaging
Tuesday, April 28, 2015
Dieter Fischer
Andrea Kaeppler
Klaus-Jochen Eichhorn
Each year, 5–13 million tons of plastic debris enter the oceans. The main reason for this is the inappropriate disposal of waste from industrialized nations.
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Identification of Recyclable Polymers with a Handheld Near-Infrared Spectrometer
Thursday, October 25, 2007
Larry P. McDermott
Robert K. Jenner
Richard A. Crocombe
Recycling of plastics and polymers, while in existence for some time, has seen significant growth driven by a combination of increasing regulation, escalating disposal costs, rising feedstock prices,...
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