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Transformation of a University Teaching Laboratory Through Innovative Solutions
Tuesday, June 01, 2010
Steve McDaniel
Michael Kihn
This article describes the improvements made to a 4500-square-foot chemistry teaching laboratory within the University of Pennsylvania’s (Philadelphia) Chemistry ’58 building. The design was led by ...
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The Benefits of Renovated Laboratories
Tuesday, June 01, 2010
Melody Spradlin
In an age of scarce financial resources and shortened deadlines, many laboratory-based organizations find that repurposing existing buildings is a less costly and faster way to bring facilities on-...
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Product Intelligence: X-Ray Fluorescence (XRF) Analyzers
Thursday, July 01, 2010
Jeffrey M. Perkel
Whatever your application, when purchasing an XRF analyzer, it all comes down to application. Elemental composition (both the range of elements in your samples and their variability), sample size and ...
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2-D in a Day: A Two-Dimensional Gel Electrophoresis Work Flow Completed in Under Five Hours
Monday, July 26, 2010
Gary B. Smejkal
Darren J. Bauer
While O’Farrell first described two-dimensional electrophoresis (2DE) of proteins 35 years ago, it remains one of the most widely used tools in proteomics today.
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The Importance of Optimizing the DNA Purification Protocol in Magnetic Particle-Based Systems
Monday, July 26, 2010
Marika Suomalainen
Sini Suomalainen
Virpi Puro
Vuokko Kytoniemi
Arja Lamberg
Magnetic particle-based techniques are widely used in many diverse biological applications, offering a relatively inexpensive technology and subjecting samples to very little mechanical stress.
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Characterization of the Daguerreotype Using the Surface Metrology Instrumental Technique of Confocal Scanning Disk Microscopy
Sunday, August 01, 2010
Patrick Ravines
Surfaces, the two-dimensional outer boundary between the three-dimensional object and its environment,have many attributes and are perceived as the complex interplay of three factors: surrounding ...
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Use of a Virtual Instrument to Measure the Mass Concentration of Nitrogen Dioxide
Sunday, August 01, 2010
Olga Kyselova
Grazina Smolianskiene
Danute Adamoniene
Danguole Kaziukoniene
Aleksej Romanov
Scientists and engineers around the world use computer software for research, design, and production. Analytical equipment manufacturers are developing the latest tools that make possible proper use ...
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Statistics in Analytical Chemistry: Part 39—Inexact Replicates: Example
Thursday, August 12, 2010
David Coleman
Lynn Vanatta
The previous installment (Part 38, American Laboratory, May 2010) outlined the regression-diagnostic steps needed when replicates are not exact.
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A Microfluidics-Based Droplet Plate Reader for Nucleic Acid and Protein Quantification
Wednesday, September 01, 2010
Tony Montoye
Life science laboratories are gradually moving toward automated liquid handling to achieve cost reduction, productivity increases, and improved data consistency and quality.
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The Road to Better Cell Culture Outcomes
Wednesday, September 01, 2010
David Craig
In an environment literally covered in microorganisms, keeping cell cultures contaminant free is both challenging and essential.
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Real-Time Detection of Central Nervous System Tissues on Bovine Carcasses Using Fluorescence Spectroscopy
Wednesday, September 01, 2010
Ramkrishna Adhikary
Prasun Mukherjee
Holger Schönenbrücher
Thomas A. Casey
Mark A. Rasmussen
Jacob W. Petrich
Bovine spongiform encephalopathy (BSE) is a fatal, neurodegenerative transmissible spongiform encephalopathy (TSE) in cattle that is thought to be the cause of variant Creutzfeldt-Jakob disease (vCJD)...
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Mercury and Arsenic Speciation Analysis by IC-ICP-MS
Wednesday, September 01, 2010
Laura Reyes
H.M. Skip Kingston
Andrea Wille
Jürgen Knöll
Alfred Steinbach
Ion chromatography (IC) with conductivity detection has been used successfully to determine anionic and cationic substances as well as polar compounds such as amines and organic acids. However, in ...
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Determination of Pesticides in Baby Food by HPLC-MS-MS Using an LC System and Triple-Quadrupole LC-MS
Wednesday, September 01, 2010
Gerd Vanhoenacker
Frank David
Pat Sandra
Due to the diversity of pesticides used in food protection and the globalization of the food industry, it is important to monitor programs that cover a large number of pesticides. The application of ...
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Multimycotoxin Screening and Quantitation in Beer Samples Using UHPLC and a High-Resolution and Accurate Mass Approach
Wednesday, September 01, 2010
Milena Zachariášová
Jana Hajšlová
Michal Godula
Mycotoxins are toxic secondary metabolites produced by many species of microscopic filamentary fungi occurring on field cereals including barley, which is used in the production of beer. The most ...
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A Novel Performance Test for Outlet Check Valve Function in HPLC Pumps
Tuesday, September 28, 2010
Eduard Rogatsky
Matthew Gallitto
Daniel T. Stein
Check valves are a vital mechanical component of HPLC pump hardware. A detailed description of check valve function and hardware designs is given in Ref. 1.
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Biological Imaging: What More Can It Provide?
Thursday, September 30, 2010
Larry Scipioni
Shawn McVey
Lewis Stern
The physicist Richard Feynman famously said in reference to (what is now called) nanotechnology, that “there is plenty of room at the bottom.”
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The Interaction Between Gemini Surfactant and Bovine Serum Albumin
Thursday, September 30, 2010
Mao Peng
Hui Wu
Lijiao Sheng
Gongwu Song
Jiangang Zhou
In recent years, Gemini surfactants have emerged as promising surface active agents.
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Strategy for Improving HPLC Retention Time Prediction Accuracy Using Chromatography Simulation Software
Friday, October 01, 2010
Alexey Makarov
Zhi Chen
Fred Chan
Rekha Bhashyam
Rosario LoBrutto
Raju Vegesna
The introduction of Quality by Design, a systematic approach to product and process design and development, has shifted the paradigm in HPLC methods development from a retrospective approach to a ...
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Automatable Processes and Future Directions in Dried Blood Spot Analysis
Friday, October 01, 2010
Chester Bowen
The application of dried blood spots (DBS) for the storage, shipment, and quantification of xenobiotics has been gaining popularity in recent years. The invention of this technology can be attributed ...
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Statistics in Analytical Chemistry: Part 40—Blanks
Friday, October 29, 2010
David Coleman
Lynn Vanatta
There are indeed statistical issues related to blanks. To set the stage, a discussion of the concept itself will be helpful.
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