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FDA Releases Encouraging Performance Metrics for Novel Drugs in 2016
Tuesday, January 10, 2017
On January 5th, the FDA released a summary of performance metrics for novel drugs introduced in 2016 and it is important to recognize that the data shows the current process for novel drug review is ...
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Super-Resolution Technology Gets a Boost From NIST’s Nanomechanical Motion Sensor
Monday, January 09, 2017
Until the super-resolution explosion, detection of small movement with light was restricted to objects larger than the diffraction limit of the light, which is a few hundred nanometers.
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Tomography for Super-Resolution 3-D and 4-D Imaging
Thursday, January 05, 2017
Compared to 2-D techniques, tomographic technology provides 3-D images with improved resolution in the z-axis.
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LASE With Nano-Lasers
Wednesday, January 04, 2017
Want to improve contrast and definition in super-resolution imaging, especially in the z-axis? A report by Sangyeon Cho and colleagues at Harvard Medical School shows that nano-lasers are a clever new...
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NGS Library Validation Using Automated Capillary Gel Electrophoresis
Friday, November 11, 2016
Next-generation sequencing (NGS) is widely used in genomics, epigenetics and transcriptomics, etc., and also in such clinical diagnostics applications as cancer screening and drug development.
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For Accurate Cell-Based Assay Results, Transfer Technique Matters
Wednesday, November 09, 2016
From smaller-scale assays to industrial-scale screening operations, cell-based assays are critical for applications that include elucidating basic mechanisms of cell function, target validation and ...
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Ten Tips for Proper Pipetting
Monday, November 07, 2016
Pipetting proficiency is one of the most critical elements to ensure accuracy and precision, particularly in the face of high personnel turnover, growing laboratory workloads and increasingly complex ...
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Achieving Accuracy and Reproducibility With Electronic Pipettes
Monday, November 07, 2016
Researchers are continuously seeking ways to improve efficiency while ensuring that their methods are reliable and their research is reproducible.
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
Beckman Coulter, Inc.
Friday, November 04, 2016
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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Cancer Throws Another Curveball
Wednesday, October 05, 2016
Metastasis of solid cancer tumors is a crucial step in progression and generally portends poor patient outcome.
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High-Throughput Drug Screening of Multicellular Tumor Spheroids
Tuesday, September 27, 2016
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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2-D NMR Developments Improve Monoclonal Antibody Characterization
Monday, September 26, 2016
Ten years ago, industry commentators noted the increasing importance of biologics, and monoclonal antibodies (mAbs), in particular.
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Automated Chromatographic Solid-Phase Extraction Using an Autosampler
Thursday, September 01, 2016
Solid-phase extraction (SPE) is a preferred tool for isolating target analytes from complex matrices because the availability of a diverse range of chromatographic sorbents enables targeted approaches...
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TERS—Ready or Not?
Thursday, September 01, 2016
Tip-enhanced Raman spectroscopy, or TERS, integrates scanning probe microscopy (SPM) for nano-scale imaging with confocal Raman spectroscopy for chemical characterization.
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No Such Thing as TMI
Friday, August 26, 2016
The June 27, 2016 issue of The New Yorker included an article by Paige Williams that detailed the work of paleoanthropologist Lee Berger, a professor of human evolution at the University of ...
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