Preparing slides for histological examination, whether for research or diagnostic purposes, is a critically important process, as the quality of preparation will directly impact the ability to accurately analyze tissues under a microscope. While there are reliable routines that many histology labs follow, such as neutral buffered formalin fixation and paraffin embedding, there are still many things that can go wrong during processing as well as many ways to improve and optimize processing procedures. The following five tips are things every histotechnologist should keep in mind while preparing samples for microscopy in order to avoid common problems and produce high quality slides for downstream examination.
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