Silica is a versatile material with many scientific applications, and serves as the basis for most columns used for reverse phase and normal phase high performance liquid chromatography (HPLC). However, not all silica columns are identical – far from it – and there are many different terms and varieties you will come across during method development and shopping for HPLC stationary phases. This article breaks down some of the main difference between common silica packing types to help lead you toward the right choice for your chromatography experiments.
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