Laboratory Conferences - Clinical Diagnostics Events

Development of an LC-ESI-MS-MS Method With Formate Anion Attachment for Detecting Neutral Molecules in Rat Plasma
Quantitative bioanalysis is the most important application area of liquid chromatography coupled with atmospheric pressure ionization (API) tandem mass spectrometric detection (LC-API-MS-MS) in ... read more
A Multifrequency Temperature- Modulated Technique For DSC
In conventional differential scanning calorimetry (DSC), a sample is subjected to a temperature program with a constant heating rate. As a result, the DSC instrument delivers an output signal, which, ... read more
Reflections on a Third-Generation Mobile Phase Recycler for HPLC
The volume of HPLC mobile phase (MP) purchased and discarded each year is about 20,000,000 L, or enough to fill two rail trains each with 100 tank cars. On average, each of the 200,000 active HPLCs... read more
The Impact of Chiral Supercritical Fluid Chromatography in Drug Discovery: From Analytical to Multigram Scale
A significant responsibility for the analytical group within Drug Discovery Chemistry at Bristol Myers-Squibb (Princeton, NJ) is the chromatographic purification of chiral compounds, both ... read more
Capillary Electrophoresis–Sodium Dodecyl Sulfate of a Heavily Glycosylated Protein: Feasibility of Stability Monitoring
In the biotechnology industry, traditional sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE)has been widely used to monitor the integrity and purity of therapeutic proteins during ... read more
A Valve Switching Ion Chromatography System With Integrated Automation Management
Valve switching applications are becoming popular in ion chromatography (IC). Example applications include matrix diversion or matrix elimination prior to analysis of trace components. read more
Evaluation of the Accuracy and Reproducibility of a High-Temperature Differential Scanning Calorimeter by Heat Capacity Measurements
Differential scanning calorimetry (DSC) is used to determine thermodynamic properties including specific heat, glass transition, and melting points of a variety of materials. The need for accurate ... read more
Enzyme Kinetics: Pushing the Final Frontier
In the current economic climate the pharmaceutical industry is focusing, more than ever, on the cost effectiveness and efficiency of drug discovery and development. read more
Capture of Green Fluorescent Protein on a High-Flow Agarose Anion Exchanger
Recent developments in upstream processing of biomolecules, driven by an increasing demand for biotherapeutics, have resulted in increased protein expression levels and larger feed volumes. read more
Multidetection Microplate Readers: Filter-Based, Monochromator-Based. . .or Both?
The appeal of multidetection microplate readers is easy to understand: they combine multiple measurement technologies such as absorbance, fluorescence,and luminescence into one compact instrument. read more
When Analyzing Cancer at the Molecular Level, Microliters Matter
This year, more than 1.4 million Americans will be diagnosed with cancer. An extremely complex disease family, cancer affects all types of people, from all nationalities and genetic make-ups. read more
Drying of Problematic Purification Samples by Lyophilization in a Centrifugal Evaporator
Lyophilization is often the preferred method of sample drying because a high level of dryness is achieved with low residual solvent levels, and because of the light, powdery, “fluffy” finish of the ... read more
Spill Prevention: Engineering Decreased Risk of Uncontained Chemical Spills
Safe solvent management and storage are significant concerns in the pharmaceutical industry, particularly when purification systems are run unattended and are supplied by large volumes of organic... read more
Statistics in Analytical Chemistry: Part 43—Pass-Fail Methods (Concluded)
The previous article (American Laboratory, Apr 2011) ended with an unsolved problem: how to implement a pass-fail method if the blank matrix contains a non-negligible amount of the analyte. read more
The Search for Promising Viral Targets in Drug Discovery
In the past decade we have seen advances in laboratory automation and in assays used to assess biological endpoints. read more

Clinical Diagnostics Events

Development of an LC-ESI-MS-MS Method With Formate Anion Attachment for Detecting Neutral Molecules in Rat Plasma

A Multifrequency Temperature- Modulated Technique For DSC

Reflections on a Third-Generation Mobile Phase Recycler for HPLC

The Impact of Chiral Supercritical Fluid Chromatography in Drug Discovery: From Analytical to Multigram Scale

Capillary Electrophoresis–Sodium Dodecyl Sulfate of a Heavily Glycosylated Protein: Feasibility of Stability Monitoring

A Valve Switching Ion Chromatography System With Integrated Automation Management

Evaluation of the Accuracy and Reproducibility of a High-Temperature Differential Scanning Calorimeter by Heat Capacity Measurements

Enzyme Kinetics: Pushing the Final Frontier

Capture of Green Fluorescent Protein on a High-Flow Agarose Anion Exchanger

Multidetection Microplate Readers: Filter-Based, Monochromator-Based. . .or Both?

When Analyzing Cancer at the Molecular Level, Microliters Matter

Drying of Problematic Purification Samples by Lyophilization in a Centrifugal Evaporator

Spill Prevention: Engineering Decreased Risk of Uncontained Chemical Spills

Statistics in Analytical Chemistry: Part 43—Pass-Fail Methods (Concluded)

The Search for Promising Viral Targets in Drug Discovery

Product Guide

What Does the Rise of Chronic Diseases Mean for the Pharma Industry?

A Make-it-or-Break-it Decision – Plastic vs. Glass Labware

The Benefits of a Variety-pack Style ULT Freezer

Cytogenetic Analysis: Selecting the Appropriate Analysis Method to Optimize Genetic Research

HEPA vs ULPA: What's the Difference?