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Clinical Diagnostics Events
The Enterovirus Outbreak in the U.S.: Should We Be Worried?
The Enterovirus D68 is spreading across North America. Thousands of children across the U.S. are reporting respiratory problems and have been found to be affected by this hitherto rare virus in this ...
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A Message from the Editor
Welcome to the October issue. In the previous month’s issue, we reflected on our approach to improvement: improving our research, as well as improving access to knowledge, methods, and personal ...
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2014 Emerging Clinical & Laboratory Diagnostics: The Portable Lab
For decades, the clinical laboratory has been recognized as the leading model for applied analytical chemistry labs. Clinical chemists are the first to deal with real-world concerns such as large-...
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Book Review: Being Mortal: Medicine and What Matters in the End
I’ve been concerned about the practice of next-generation sequencing (NGS), especially about what information is generated and how it will be used. Thus, a colleague suggested that I read Being ...
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Observations on Regulatory RNAs 2014
The last two decades have been exciting times as simplistic genomic models were updated to explain mechanistic details. Along the way, we discarded the expectation that sequencing the genome would ...
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A Message from the Editor
Welcome to the November/December issue. In the last issue, I encouraged all of you to take a moment and think about what you can do differently to optimize productivity and efficiency in your ...
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Next-Generation Sequencing for Disease Biomarkers
Next-generation sequencing (NGS) is beginning to provide powerful insights into genetic mutations and molecular networks underlying disease for a broad set of genes. NGS technologies promise to ...
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Analysis of Hemoglobin Variants using an Automated Sample Preparation Workstation Coupled to LC-MS
Hemoglobinopathies are genetic defects that result in one of the chains of the hemoglobin molecule. These are usually single-gene disorders, such as sickle cell disease, and they are usually ...
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A Molecular Diagnostic Platform for Use in the Physician’s Office to Treat Infectious Disease
The current standard of care for infectious disease management typically involves a nucleic acid amplification test (NAAT) to produce a definitive diagnosis. Due to the complexity of molecular ...
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Point-of-Care Diagnostics at the 22nd International Molecular Medicine Tri-Conference
Point-of-care diagnostics (POC) was an important track at the 22nd International Molecular Medicine Tri-Conference, held February 15–20, 2014, in San Francisco, Calif. According to Jeffrey DuBois, Ph....
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Liquid Biopsy Symposium at Molecular MedTri-Con 2015
The hottest track at the 2015 Molecular Med Tri-Con was circulating nucleic acids. Circulating tumor cells were also sizzling, leading to the question: “Which is most important?”
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Liquid Biopsy Symposium at Molecular Med Tri-Con 2015
The hottest track at the 2015 Molecular Med Tri-Con was circulating nucleic acids. Circulating tumor cells were also sizzling, leading to the question: “Which is most important?” The answer? Both, ...
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Liquid Biopsy Solutions for Noninvasive Molecular Profiling
Liquid biopsy offers the potential to understand and treat cancer in ways never before possible. The concept is simple: collect tumor DNA after it enters the peripheral blood circulation and identify...
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A Review of Quetzal: A Linguistic Search Engine for Biomedical Literature
Quetzal is a biomedical literature search engine that uses simple strategies that contain few keywords combined with an extensive biomedical vocabulary and filter sets that mirror the discovery ...
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Reference Standards Address Technical Challenges in DNA Resequencing
The extensive workflow required to analyze DNA samples using next-generation sequencing (NGS) leaves many opportunities for the introduction of variability.
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