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Thin-Layer Chromatography/Mass Spectrometry Analysis of Sample Mixtures Using a Compact Mass Spectrometer
Thin-layer chromatography (TLC) is a planar chromatographic technique used to separate the components of a mixture by employing a thin stationary phase supported by an inert backing. It can be ...
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Linear Transformation Applied to the Calibration of Analytes in Various Matrices Using a Total Hydrocarbon Analyzer
Total hydrocarbon analyzers provide linear responses to methane and other hydrocarbons; however, the slope and intercept measurements are dependent on the matrix. This requires that calibration be ...
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Evolving Software Enables Smarter Workflows: An Interview With Gene Tetreault of BIOVIA
The digital revolution in the laboratory began in the late 1960s, with digital integrators measuring the area of chromatographic peaks in microvolt seconds.
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Glycoxidative Modification of Adenosine in Relation to Diabetes and Obesity: Detection of Carboxymethyl-Adenosine in Biological Samples
Proteins are modified in residues of lysine, arginine, histidine, etc., due to high concentrations of sugar and fatty acids in the bloodstream in relation to diabetes.
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Use of Weighted Least Squares and Confidence Band Calibration Statistics to Find Reliable Instrument Detection Limits for Trace Organic Chemical Analysis
Instrument detection limits (IDLs or xD) obtained from applying either ordinary least squares/confidence band calibration statistics (OLS/CBCS) or weighted least squares/confidence band calibration ...
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Recent Advances in ICP Spectrometers
When SPECTRO Analytical Instruments (Kleve, Germany) sought to redesign its inductively coupled plasma (ICP) spectrometer instrument line, the company’s engineers worked to address some very specific ...
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Statistics in the Laboratory: A New American Laboratory Column
Welcome to “Statistics in the Laboratory.” This column will appear four times a year and will build on the popular “Statistics in Analytical Chemistry” series by David Coleman and Lynn Vanatta ...
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Five Ways to Improve the Workflow and Financial Health of the Laboratory
Henry Ford quipped, “There are no big problems; there are just a lot of little problems.”
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Integration—The Missing Link in Data-Rich Research: Interview With Robert Stanley of IO Informatics
Science-driven decisions depend on data, both structured (in tables) and from notes (natural language).
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SPE Method to Eliminate Matrix Effect in the LC/MS (TOF) Analysis of Illicit NBOMe Synthetic Hallucinogens from Urine
The high specificity of LC/MS is relied upon for detecting illicit compounds. However, issues related to method robustness and matrix interference have driven the need for developing better analytical...
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Statistics in the Laboratory: Control Charts, Part 1
Statistical process control (SPC) charts were introduced briefly in the previous column (October 2015).
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Computer-Assisted Structure Elucidation in Routine Analysis
The elucidation of unknown structures, especially those with novel moieties found in natural products, often results in initially incorrect published structures, which then require either exhaustive ...
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Determination of Sulfur Compounds in Natural Gas and Gaseous Fuels by Gas Chromatography and Pulsed Flame Photometric Detection
The carbonated beverage and petrochemicals industries are just some areas in which the analysis of volatile sulfur-containing compounds in process streams is a critical quality-control step.
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Using a Standard Bath Circulator as a Calibration Device
This technical note will review the considerations for using a standard bath circulator or water bath as a calibration instrument instead of a purpose-built calibration bath.
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Link Connects Instruments with Cloud, Centralizes Remote Control, Monitoring and Data Storage
The TetraScience Link (TetraScience Inc., Boston, Mass.; www.tetrascience.com) is a small Wi-Fi and ethernet-enabled hardware module that connects instruments and sensors to a centralized cloud-based ...
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