Application Notes

Sort

Securing the Energy Future: Work Flow Solutions for Biodiesel Quality Control
Monday, May 23, 2011
Paul Wheeler
The global energy crisis is starting to have a significant impact on the world economic climate. Read More
GC Analysis of Sulfur Components in Propylene Using a Pulsed Flame Photometric Detector
Monday, May 23, 2011
Helena Jacobse
Hydrogen sulfide (H2S), carbonyl sulfide (COS), and methyl mercaptan (CH3SH) are common components in light hydrocarbon streams. Read More
Dynamic Light Scattering For the Noninvasive Detection of Protein Aggregation
Wednesday, February 01, 2006
Bernard Lorber
Protein homogeneity is an important issue in many fields of research, be it the characterization of newly isolated molecules, the identification of crystallizable samples, or the preparation of ... Read More
Improved Capabilities of Noncell-Based Permeability Assays
Monday, April 10, 2006
Greg Kazan
Assays that predict passive absorption of orally administered drugs have become increasingly important in the early drug discovery process. Read More
Single-Step Purification of Lactase From a New Isolate of L. acidophilus
Wednesday, February 01, 2006
Sameer K. Akolkar Smita S. Lele
Lactase (ß-D-galactohydrolase EC 3.2.1.23) is widely distributed in microorganisms, plants, and animals. Read More
The Future of Information Technology: Selecting a Forward- Looking LIMS Vendor
Friday, March 10, 2006
David Leitham
Most sophisticated LIMS purchasers have a well-developed methodology for evaluating which system best meets their needs. Read More
Nitrogen Generation in an Environmental Testing Laboratory
Thursday, September 07, 2006
Phillip Allison
Belmont Labs, located in Englewood, OH, is an environmental testing facility offering analytical services to clients in industry, civil/environmental engineering, and state and local governments. Read More
Managing Laboratory Maintenance
Tuesday, February 07, 2006
L. Wayne Collins
Other than personnel-related costs, maintenance is generally the most expensive item in the laboratory operating budget. Read More
Aligning Ultrafast NMR Spectroscopy and Cold Probe Technology to Reveal the Mysteries of Protein Dynamics
Wednesday, March 01, 2006
Judit Losonczi Eriks Kupce George Gray Peter Sandor Bernhard Brutscher
The understanding of protein dynamics, the way these molecules fold to form a stable structure, interact with other molecules, or undergo changes during enzyme activity, etc., in their native ... Read More
Breakthrough Technology for Bottom-Up Proteomics and Small Molecule Research
Tuesday, August 01, 2006
Alexander Makarov Helmut Muenster
High mass resolution is a prerequisite for high mass accuracy. Both are key for the analysis of unknown samples. High resolution enables the separation and detection of isobaric signals that are ... Read More
Dielectrophoretic Force Microscopy
Wednesday, January 19, 2005
Al M. Hilton Brian P. Lynch Garth J. Simpson
Dielectrophoresis (DEP), the force exerted on a polarizable particle in a nonuniform electric field, has been used with great success in recent years to manipulate and separate cells and biomolecules. Read More
Stability of Salicylic Acid and Magnesium Stearate by DSC
Saturday, April 01, 2006
Steven Sauerbrunn Lloyd MacPherson
The first step in developing effective pharmaceutical formulations is the discovery of the active agent. Read More
Defragmenting Chiral Chromatography
Wednesday, February 01, 2006
Regina Valluzzi Benjamin Chaloner-Gill
Chiral molecules continue to drive growth across a number of industries as new chemistries, active ingredients, and products are developed and commercialized. Read More
A Multifrequency Temperature- Modulated Technique For DSC
Sunday, January 01, 2006
Markus Schubnell Christoph Heitz Thomas Hütter Steven Sauerbrunn Juergen E.K. Schawe
In conventional differential scanning calorimetry (DSC), a sample is subjected to a temperature program with a constant heating rate. As a result, the DSC instrument delivers an output signal, which, ... Read More
The Impact of Chiral Supercritical Fluid Chromatography in Drug Discovery: From Analytical to Multigram Scale
Thursday, June 01, 2006
Dauh-Rurng Wu Leslie Leith Balu Balasubramanian Todd Palcic David Wang-Iverson
A significant responsibility for the analytical group within Drug Discovery Chemistry at Bristol Myers-Squibb (Princeton, NJ) is the chromatographic purification of chiral compounds, both ... Read More
Evaluation of the Accuracy and Reproducibility of a High-Temperature Differential Scanning Calorimeter by Heat Capacity Measurements
Tuesday, August 01, 2006
Susan Jacob Mark E. Schlesinger
Differential scanning calorimetry (DSC) is used to determine thermodynamic properties including specific heat, glass transition, and melting points of a variety of materials. The need for accurate ... Read More
Enzyme Kinetics: Pushing the Final Frontier
Monday, June 06, 2011
Marika Raitio Reija- Riitta Harinen Jorma Lampinen
In the current economic climate the pharmaceutical industry is focusing, more than ever, on the cost effectiveness and efficiency of drug discovery and development. Read More
Capture of Green Fluorescent Protein on a High-Flow Agarose Anion Exchanger
Thursday, June 01, 2006
Anna Åkerblom Mattias Bryntesson Eggert Brekkan Kjell Eriksson
Recent developments in upstream processing of biomolecules, driven by an increasing demand for biotherapeutics, have resulted in increased protein expression levels and larger feed volumes. Read More
Drying of Problematic Purification Samples by Lyophilization in a Centrifugal Evaporator
Monday, June 13, 2011
Induka Abeysena Rob Darrington
Lyophilization is often the preferred method of sample drying because a high level of dryness is achieved with low residual solvent levels, and because of the light, powdery, “fluffy” finish of the ... Read More
Cell-Based Biosensors: A Quartz Crystal Microbalance Approach to Membrane Protein Interaction Studies
Monday, June 13, 2011
Karin Elovsson Zhichao Pei Teodor Aastrup
Drug development today is a time-consuming and expensive business, with costs reaching over $1 billion from drug discovery to market. Read More