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Date Published
Title
Is This Surface Clean? Cleaning Validation by Direct Spectroscopic Surface Analysis
Friday, September 01, 2006
Mary Thomson
Peter Melling
Pharmaceutical manufacturers and formulators must be able to confirm that the equipment they use is clean before it is utilized.
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Saving Money on TOC Analyzer Gas Costs
Friday, September 01, 2006
Jennifer Triplett
Total organic carbon analyzers are increasingly popular as an accurate and inexpensive way to test for inorganic and organic carbon contamination in water samples.
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The Determination of Perchlorate in Water Using LC-MS-MS
Friday, September 01, 2006
Joseph Romano
Perchlorate is both a naturally occurring chemical and a man-made inorganic ion.
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Pressure Digestion or Microwave Pressure Digestion for Sample Preparation?
Tuesday, August 01, 2006
Dieter Gutwerk
Element determination in solids is a multiple-stage process comprising sampling, mechanical sample preparation, and acid digestion procedures that completely convert the analytical materials into ...
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Evaluation of the Accuracy and Reproducibility of a High-Temperature Differential Scanning Calorimeter by Heat Capacity Measurements
Tuesday, August 01, 2006
Susan Jacob
Mark E. Schlesinger
Differential scanning calorimetry (DSC) is used to determine thermodynamic properties including specific heat, glass transition, and melting points of a variety of materials. The need for accurate ...
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Breakthrough Technology for Bottom-Up Proteomics and Small Molecule Research
Tuesday, August 01, 2006
Alexander Makarov
Helmut Muenster
High mass resolution is a prerequisite for high mass accuracy. Both are key for the analysis of unknown samples. High resolution enables the separation and detection of isobaric signals that are ...
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The Impact of Chiral Supercritical Fluid Chromatography in Drug Discovery: From Analytical to Multigram Scale
Thursday, June 01, 2006
Dauh-Rurng Wu
Leslie Leith
Balu Balasubramanian
Todd Palcic
David Wang-Iverson
A significant responsibility for the analytical group within Drug Discovery Chemistry at Bristol Myers-Squibb (Princeton, NJ) is the chromatographic purification of chiral compounds, both ...
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Capture of Green Fluorescent Protein on a High-Flow Agarose Anion Exchanger
Thursday, June 01, 2006
Anna Åkerblom
Mattias Bryntesson
Eggert Brekkan
Kjell Eriksson
Recent developments in upstream processing of biomolecules, driven by an increasing demand for biotherapeutics, have resulted in increased protein expression levels and larger feed volumes.
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A Programmable Homogenizing System for Enhanced Productivity and Efficiency
Thursday, June 01, 2006
Karl Jahn
The trend in many of today’s laboratories is toward high throughput and low-volume samples.
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Application of Difference Spectroscopy to Biopharmaceutical Formulation Development
Monday, May 01, 2006
John S. Vrettos
Richard P. Affleck
Jing Guo
Thomas M. Spitznagel
Rajesh Krishnamurthy
Spectroscopy is increasingly being used in biopharmaceutical formulation development to characterize protein structure and the response of structure to the formulation configuration.
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Improved Capabilities of Noncell-Based Permeability Assays
Monday, April 10, 2006
Greg Kazan
Assays that predict passive absorption of orally administered drugs have become increasingly important in the early drug discovery process.
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Managing Workstation Exhaust at Biosafety Level Laboratories
Monday, April 03, 2006
Paul A. Tetley
Biosafety level laboratories, particularly Levels3 and 4, present special problems for managing workstation fumehood exhaust.
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A Colloid Stability Analyzer for the Analysis of Stability of Complex Formulations
Saturday, April 01, 2006
Breda O’Driscoll
Vitaly Buckin
Scientists in the biotechnology, pharmaceutical, health-care, food and beverage, chemical and petrochemical, polymer, and other industries have spent considerable time studying the relationship ...
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Comprehensive Two-Dimensional Gas Chromatography With a Simple Fluidic Modulator
Saturday, April 01, 2006
John V. Seeley
Nicole J. Micyus
James D. McCurry
Stacy K. Seeley
Gas chromatography is a simple yet powerful technique for analyzing complex mixtures of volatile and semivolatile compounds.
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Stability of Salicylic Acid and Magnesium Stearate by DSC
Saturday, April 01, 2006
Steven Sauerbrunn
Lloyd MacPherson
The first step in developing effective pharmaceutical formulations is the discovery of the active agent.
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The Future of Information Technology: Selecting a Forward- Looking LIMS Vendor
Friday, March 10, 2006
David Leitham
Most sophisticated LIMS purchasers have a well-developed methodology for evaluating which system best meets their needs.
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Aligning Ultrafast NMR Spectroscopy and Cold Probe Technology to Reveal the Mysteries of Protein Dynamics
Wednesday, March 01, 2006
Judit Losonczi
Eriks Kupce
George Gray
Peter Sandor
Bernhard Brutscher
The understanding of protein dynamics, the way these molecules fold to form a stable structure, interact with other molecules, or undergo changes during enzyme activity, etc., in their native ...
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Managing Laboratory Maintenance
Tuesday, February 07, 2006
L. Wayne Collins
Other than personnel-related costs, maintenance is generally the most expensive item in the laboratory operating budget.
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Defragmenting Chiral Chromatography
Wednesday, February 01, 2006
Regina Valluzzi
Benjamin Chaloner-Gill
Chiral molecules continue to drive growth across a number of industries as new chemistries, active ingredients, and products are developed and commercialized.
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Single-Step Purification of Lactase From a New Isolate of L. acidophilus
Wednesday, February 01, 2006
Sameer K. Akolkar
Smita S. Lele
Lactase (ß-D-galactohydrolase EC 3.2.1.23) is widely distributed in microorganisms, plants, and animals.
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