Application Notes

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Impurity Evaluation of Heparin Sodium by Anion Exchange Chromatography
Thursday, October 01, 2009
Catalin E. Doneanu Weibin Chen
As a blood-thinning drug, heparin and its derivative, low-molecular-weight heparin (LMWH), have been widely used for decades during surgery and kidney dialysis. Read More
1-mm-i.d. Monolithic HPLC Columns for High-Efficiency Protein Separations
Tuesday, September 01, 2009
Sebastiaan Eeltink Remco Swart
The preparation of monolithic separation media for HPLC composed of a single, continuous polymer macroporous support has been reported since the late 1960s. Due to its unique material properties, ... Read More
Knowledge Management and Efficiency Gains
Tuesday, September 01, 2009
Paul Denny-Gouldson Eliot Randle
In the face of escalating R&D costs, currently estimated at $800 million U.S. to produce a new drug, the life science discovery industry is constantly searching for ways to control expenditure, ... Read More
Dietary Supplement Standard Reference Materials
Thursday, October 01, 2009
Lane C. Sander Karen W. Phinney Michele M. Schantz Katherine E. Sharples Stephen A. Wise
In 1994, the U.S. Congress enacted the Dietary Supplement Health and Education Act (DSHEA) to "protect the right of access of consumers to safe dietary supplements." One way in which this is expected ... Read More
Reduced Carryover Using an LC Autosampler System
Thursday, October 01, 2009
Osamu Shirota Kazuhiko Mibayashi Yasutaka Naruse Masashi Mita
Recent high-sensitivity and high-throughput trends in liquid chromatography,influenced largely by the latest interfacing technologies of mass spectrometry, seem to demand further improvements in ... Read More
Fluorescence Microscopy: Solving Common Documentation Challenges
Sunday, November 01, 2009
Mark Clymer
Fluorescence has proven to be a useful technique for identifying, tracking, and studying molecules of interest in biological specimens. In fact, fluorescence is among the fastest growing microscopy ... Read More
Use of an Automated Microscope Platform for Protein and Small-Molecule Crystal Harvesting
Sunday, November 01, 2009
Tom Friedlander
A standard laboratory microscope is a necessary tool in almost every laboratory in the world. While electron, fluorescence, confocal, and atomic force microscopes (AFMs) are gaining in popularity, the... Read More
Advances in Cryo-SEM: From Micrometers to Nanometers
Sunday, November 01, 2009
Jens Greiser
Science is driving the demand for nanoscale resolution. Cryo-scanning electron microscopy (cryo-SEM), which combines the high-performance imaging of scanning electron microscopy (SEM) with cryogenic ... Read More
The Helium Ion Microscope: Advances in Technology and Applications
Sunday, November 01, 2009
Larry Scipioni Paul Alkemade Vadim Sidorkin Ping Chen Diederik Maas Emile van Veldhoven
Helium ion microscopy (HIM) offers the highest spatial resolution surface imaging of any scanning beam method, as well as extremely high surface sensitivity. Read More
Choosing Solvent Packaging to Increase Laboratory Efficiency and Quality While Reducing Waste Disposal Costs
Monday, November 01, 2010
Jim Westra Qing Ping Han Paul McCoy Rosanne Isom Mark Hayward
Laboratory scientists have a finite number of work hours to accomplish their required research. The annual cost of a scientist and laboratory space for this research in today’s modern, instrument ... Read More
Decoding the Nanoworld: Pushing the Envelope in Atomic Force Microscopy
Friday, April 17, 2009
Mario Viani Roger Proksch Jason Cleveland Monteith G. Heaton
Over the past decade, atomic force microscopy/scanning probe microscopy (AFM/SPM) has emerged as the leading tool for investigations at the nanoscale—doing everything from imaging, to compositional ... Read More
Why Managed Maintenance is the HMO of Laboratory Instrumentation Repair and Maintenance
Friday, February 20, 2009
Mark Circo
Our industry has undergone some dramatic changes in the past few years. Managed maintenance developed as a way for universities and large laboratories to save money on the annual maintenance of their ... Read More
Take the Laboratory With You: Portable XRF
Thursday, February 26, 2009
Jeffrey Henseler
Energy dispersive X-ray fluorescence (ED-XRF) instruments perform nondestructive analysis of a wide range of elements with accuracy and precision. They are relatively inexpensive and are an excellent ... Read More
Application of UPLC Amino Acid Analysis Solution to Foods and Feeds
Sunday, February 01, 2009
Thomas E. Wheat Hillary B. Hewitson Diane M. Diehl
Amino acid analysis has been used in the food and feed industries to verify and characterize materials and processes. The total amino acid content, as well as the proportions of growth-limiting amino ... Read More
Utilization of a TOC Analyzer for Low-Level Sample Analysis
Friday, January 23, 2009
Stephen C. Lawson
In a variety of industrial and environmental applications, the measurement of total organic carbon in water is an important analytical parameter in evaluating water quality. The Fusion analyzer and ... Read More
Analysis of Oxygenates in Gasoline by Multidimensional Gas Chromatography
Sunday, February 01, 2009
Takaaki Hiraoka Mikiko Asakawa Toyohito Wada Masanao Furukawa Yasunori Terai
The quantitative measurement of oxygenated compounds such as alcohols and ethers in gasoline by gas chromatography is difficult, because a single column for the complete separation of the target ... Read More
A GC Tool to Ensure Precise GC Column Installation for Method Sensitivity and Reproducibility
Sunday, February 01, 2009
Kory Kelly
Correct and precise gas chromatography column installation is critical to system performance. Columns that are installed at an improper or inconsistent depth will adversely affect analyte response and... Read More
Measuring the Heat of Evaporation by TGA/DSC
Thursday, January 01, 2009
Steve Sauerbrunn Michael Zemo
Heat of evaporation is the amount of heat required to make a physical change from the liquid phase to the gas phase. Read More
The Use of Pressurized Liquid Dispensing Containers (PLDCs) With Flammable Liquids in Laboratories
Thursday, January 01, 2009
Jim Westra
Large quantities of flammable solvents are used in today’s high-throughput analytical and biopharmaceutical laboratories. To minimize hazards, these laboratories have tried to adopt alternative ... Read More
Reliable and Effective Trace-Level Total Sulfur Determination Using New Injection and Combustion Technologies
Thursday, February 26, 2009
Rene van der Windt Arthur van Strien
Total sulfur and nitrogen (TS/TN) levels are commonly used parameters in the petrochemical, natural gas, and oil refining industries, and the need for their determination is growing due to the ... Read More