Technical Articles

Surface-enhanced laser desorption time-of-flight mass spectroscopy is a bioanalytical technique used for the rapid examination of intact protein or protein mixtures to exploit the biochemical or ... read more

In various recent interviews, I’ve been asked about the state of microscopy and, most specifically, the rise of technologies such as AFM (atomic force microscopy) and Raman confocal and the ... read more

An air-cooled tube in a laboratory furnace (crystallization shelf) that regulates the crystallization fronts and rates in columns of crucibles was described in a previous paper. read more

Never before have I attended a meeting that concisely addressed so many topics of current public concern. read more

Discussions on the use of the Tag-lite® platform for G protein-coupled receptor (GPCR) applications have revolved solely around affinity or potency and the calculation of the Kd output, greatly ... read more

From the dramatic increase in new fluorophores to the proliferation of techniques like total internal reflection fluorescence (TIRF), photoactivated localization microscopy (PALM), and stochastic... read more

Imagine that a new method has been developed and now needs a calibration curve. read more

Society has invested tens of billions of dollars in the last two decades to sequence the human genome and look for biomarkers to fight disease and guide therapy. read more

Many samples contain not only neutral hydrophobic analytes, commonly determined using reversed-phase (RP) HPLC, but ionic analytes. read more

Testing hair for drugs of abuse has been practiced for over 50 years, due in large part to the ability to detect drug use over a longer period of time, as compared to other biological matrices, ... read more