In the last two decades, cryomicroscopy methods have become widespread and effective tools used by life scientists, pharmaceutical researchers, and more, to examine biological structures close to their native state.1 The capabilities of cryomicroscopy to visualize the structure of biological molecules, such as proteins and protein complexes, make a valuable addition to existing methods such as X-ray crystallography and nuclear magnetic resonance (NMR). Determining the structure of proteins and protein complexes, which are of particular interest as drug targets and are the subject of investigation to gain a deeper understanding of disease mechanisms, is an important element of drug discovery.
In this article, we will take a look at the use of cryomicroscopy techniques, including cryo-correlative light and electron microscopy (cryo-CLEM), freeze-drying microscopy (FDM), and cryopreservation in pharma research, and how temperature-controlled microscopy stages are enabling researchers to advance drug discovery and development studies at cryogenic temperatures.
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