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Title
Optical Tweezers for Single-Cell, Multicellular Investigations in the Life Sciences
Thursday, November 26, 2015
Torsten Jähnke
Philipp Rauch
With accuracy down to single piconewtons, optical traps measure forces exerted on microscopic objects without mechanically touching them.
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Getting the Most Out of Limited Samples: A PCR Workflow for Monitoring Gene Expression
Tuesday, November 24, 2015
Joshua Fenrich
Seeking to identify the biochemical triggers that commit stem cells to distinct fates, researchers at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital in Toronto assessed the culture...
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The Road to Improved Next-Generation Sequencing Through Innovative PCR Instrumentation
Friday, November 20, 2015
Andrew Birnie
Next-generation sequencing (NGS), one of the most significant technological advances in the the last 30 years, allows millions of DNA strands to be sequenced in parallel.
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In-House Pipette Calibration: The Lean Way
Thursday, October 08, 2015
A. Björn Carle
Sorenson Genomics of Salt Lake City focuses on DNA testing, with its expertise in quality, high-throughput testing that spans several diverse business units and highly accredited laboratories.
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Examining the Multiple Parameters of Glycolytic Activity
Monday, September 28, 2015
Maya Dubey
Cellular energy enables vital activities such as proliferation, differentiation, stimuli response and intracellular signaling.
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Quantitative Analysis of H2A.X and ATM DNA Damage Signals Using Benchtop Flow Cytometry
Friday, September 25, 2015
Mark Santos
Wenying Zhang
Assessing the level of DNA damage present in cells is integral to understanding the molecular mechanisms involved in the genome repair process and consequences for cell fate.
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Simple Cell Imaging for Complex Research
Monday, September 21, 2015
Veronika Kortisova Descamps
The average rat brain is about the size of a pea and is divided into more than a dozen functional structures.
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A Review of Quetzal: A Linguistic Search Engine for Biomedical Literature
Wednesday, August 05, 2015
C. Tobin Magle
Quetzal is a biomedical literature search engine that uses simple strategies that contain few keywords combined with an extensive biomedical vocabulary and filter sets that mirror the discovery ...
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Automating and Validating Analysis in High-Throughput Single-Cell Assays
Monday, June 15, 2015
Ian Taylor
Jay Almarode
Michael D. Stadnisky
While genomics and transcriptomics provide insight into the potential of a cell, single-cell phenomic data reflect its current reality, allowing researchers to determine how genomic variants affect ...
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Screening Live Cells Using RNA Detection Probes
Friday, June 12, 2015
Don Weldon
Harald Lahm
RNA expression is the next frontier in biomarker development because it offers an indication of cellular intent. mRNA expression, in particular, can show how a cell responds to its environment or ...
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Use of Heat Stabilization to Preserve Lipids and Improve Sample Quality
Friday, June 12, 2015
Marcus Söderquist
Lipids have long been considered to be mere building blocks of cell membranes or energy-storage molecules. It is now evident, however, that these small, nonpolymeric molecules play several key roles ...
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How to Choose Between a CCD and sCMOS Scientific-Grade Camera
Wednesday, April 29, 2015
James Joubert
Cell biologists require microscopy tools that can detect rapid movements within a cell with detail and sensitivity in low light conditions. Developers must address performance requirements, and be ...
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An Automated System to Improve Western Blot Processing
Wednesday, April 22, 2015
Alexander Margulis
Angela M. Zaorski
David P. Chimento
Russ Yukhananov
Western blot assays provide important information about the presence and levels of protein expression. The first step in the procedure is the lysis of cells or tissues followed by solubilization of ...
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Validation of a Magnetic Bead Mixer on an Automated Next-Generation Sequencing Library Preparation System
Tuesday, April 07, 2015
Sikander Gill
Rajwant Gill
Nick Bandy
Dong Liang
Reduced costs and higher throughput have made next-generation sequencing (NGS) more accessible to users in such diverse fields as diagnostics, infectious disease, food safety and public health. NGS ...
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Interview with Udit Batra, President and CEO, EMD Millipore
Tuesday, November 25, 2014
Emilia Raszkiewicz
ER: I am aware that there have been many exciting business developments within EMD Millipore in the past year, including your appointment as CEO and President. I trust that our discussion will give ...
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True Hypoxia Replication: Creating Optimal Conditions for Cell-Based Research
Monday, November 10, 2014
Michael Rau
There is a rapidly growing need for systems capable of creating precise, reproducible, and physiologically relevant cell environments in the laboratory in order to enable accurate analysis of both ...
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An Improved Method to Generate Virus-Free Human iPSCs
Monday, November 03, 2014
Vi Chu
Nick Asbrock
Min Lu
Induced pluripotent stem cells (iPSCs) are offering new opportunities in both research and clinical applications. Researchers are using these cells for drug and toxicity screening, as well as for ...
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A Portable CGE-Based Biomolecule Detection System Using a Smartphone App for Operation via WiFi
Monday, October 27, 2014
Varouj Amirkhanian
Eric Tsai
Allen Chi
Myron Yu
Hsinhan Huang
Most bioseparation and detection tools used in the laboratory employ slab gel-based electrophoresis technologies, which have routinely been used for the analysis of biomolecules (i.e., DNA, RNA, ...
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Enabling Cancer Research and Treatment With Droplet-Based Digital PCR Technology
Wednesday, September 03, 2014
George Karlin-Neumann
Cancer research is as necessary as ever, especially if we are to fulfill the promise of personalized (or “precision”) medicine based on specific cancer therapies directed to known molecular targets.
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Electrophoresis 2.0: Faster, Stronger, and More Reproducible
Monday, August 04, 2014
Ryan Jensen
Stefan Lehr
Anton Posch
In 2010, researchers around the world were competing to finish the race to purify BRCA2, a protein whose mutant form is associated with more than 50% of hereditary breast cancer. But only one of ...
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