June/July 2015
Volume 47, Number 5
Of note in this issue is a triple quadrupole GC/MS/MS operating in the multiple reaction monitoring mode to detect targeted drugs with high sensitivity. Another article describes TASC (thermal analysis by structural characterization) for characterizing pharmaceuticals and polymers in combination with light microscopy and differential scanning calorimetry.
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Table of Contents
Steve Ernst
Less is more, except for some literal-minded folks who think more is more. Go figure. The phrase “less is more” came to mind as I was thinking about thinking.
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Robert L. Stevenson, Ph.D.
About 80% of the imprecision in analytical results has been attributed to the preanalytics stage of the assay. Sample preparation, including human manipulations, receives most of the blame.
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Ian Taylor, Jay Almarode, Michael D. Stadnisky
While genomics and transcriptomics provide insight into the potential of a cell, single-cell phenomic data reflect its current reality, allowing researchers to determine how genomic variants affect ...
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Richard Whitney, Laura Chambers
Developing methods for the analysis of drugs of abuse has become a priority for forensic toxicology and law enforcement. The large variety of illicit drugs and new and so-called “designer
drugs” has ...
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Emilia Raszkiewicz
This article outlines the components of an HPLC system, from solvent reservoir to solvent pump to injector, column and data processing unit. Types and applications of HPLC instruments are provided, ...
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W.A. Hammond received his Ph.D. from Ohio
State in 1929 for research on the behavior of the
various hydrates of calcium sulfate in the naturally
occurring mineral gypsum. This research
led to the ...
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Robert L. Stevenson, Ph.D.
The hottest track at the 2015 Molecular Med Tri-Con was circulating nucleic acids. Circulating tumor cells were also sizzling, leading to the question: “Which is most important?” The answer?
Both, ...
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The quality and composition of chemical products used in research are ensured by various organizations such as the American Society for Testing and Materials and the National Institute of Standards ...
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Mike Reading, Duncan Stacey
Thermal analysis by structural characterization
(TASC) combines with differential scanning calorimetry (DSC) and light microscopy to provide a powerful technique for characterizing polymers, ...
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Michael Schwartz
Liquid biopsy offers the potential to understand
and treat cancer in ways never before possible. The concept is simple: collect tumor DNA after it enters the peripheral blood circulation and identify...
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Marcus Söderquist
Lipids have long been considered to be mere building blocks of cell membranes or energy-storage molecules. It is now evident, however,
that these small, nonpolymeric molecules play several key roles ...
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Harald Lahm, Don Weldon
RNA expression is the next frontier in biomarker development because it offers an indication of cellular intent. mRNA expression, in particular, can show how a cell responds to its environment or ...
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