Application Notes

Sort

Testing and Troubleshooting Liquid Chromatography Method Transfer
Friday, November 10, 2017
Paula Hong Jinchuan Yang Mark Benvenuti Gareth Cleland Patricia McConville
Factors that affect method transfer are discussed, particularly as they relate to the analysis of isoflavones in soy extract. Read More
Impact of Weighing Accuracy and Data Integrity in Forensic Drug Analysis
Friday, November 10, 2017
Tucker Rubino Klaus Fritsch Thomas Rohrer
To stay compliant with ever-changing regulations and withstand any challenge in court, it is critical for managers and scientists in forensic laboratories to be well-informed about the key issues ... Read More
Comparing the Stability of Protein Formulations
Friday, November 10, 2017
Michael Drenski
Because most therapeutic protein formulations are difficult and expensive to produce at high yields, biopharma companies need tools that provide rapid, high-quality protein stability information with ... Read More
Next-Generation Software for Food and Forensic Laboratories
Friday, November 10, 2017
Phil Taylor
Food testing and forensic laboratories want to maximize productivity, deliver better-quality data, and remove the element of risk associated with manual interpretation, and the right software is ... Read More
Isothermal Titration Calorimetry: An Indispensable Tool for Biological Pathway Research and Drug Development
Monday, October 02, 2017
Verna Frasca
As our knowledge of the genetic and molecular basis of disease continues to grow, drug development programs focus increasingly on those proteins associated with disease states. Read More
ASTM-Approved Method for Simultaneous Determination of Total Nitrogen and Phosphorus in Wastewater by Ion Chromatography
Monday, October 02, 2017
Jeff Rohrer Richard Jack Brian De Borba
As natural elements in aquatic ecosystems, nitrogen and phosphorus support the growth of algae and aquatic plants, providing food and shelter for fish and other organisms. Read More
Ion-Moderated Partitioning for Carbohydrate Analysis
Friday, September 29, 2017
Payal Khandelwal Mona Chin Anna Quinlan
This article discusses ion-moderated partitioning, a form of normal-phase HPLC for carbohydrate analysis that is often referred to as ion chromatography and is commonly used in the food and ... Read More
Best Practices for Circulating Baths When Measuring Viscosity Temperature Profiles
Friday, September 29, 2017
Robert G. McGregor
Best practices are given to ensure that bath performance meets the laboratory's needs for precise temperature control. Read More
Automated Nephelometric Turbidity Measurement of Biotherapeutics Formulations
Friday, September 29, 2017
Daniel Kinder
With accurate turbidity data, the Freeslate biologics formulation workstation provides rapid sample preparation and analysis to support drug discovery and development activities. Read More
Beyond the Limit: The World of Super-Resolution Microscopy
Friday, September 29, 2017
Russell Ulbrich
Scientists are using super-resolution microscopy to image living samples well beyond the established theoretical limit, allowing the study of far-ranging biological phenomena. Read More
Product Contamination Visualization and Identification Using FTIR Microspectroscopy
Friday, September 29, 2017
David W. Schiering Anthony W. Didomenico John A. Seelenbinder
The identification of surface contamination particles on products is demonstrated using a new FTIR microspectroscopy accessory. Read More
Bioparticles, Molecules, and Complexes Analyzed by “Chromatography” Without a Stationary Phase
Friday, September 29, 2017
David M. Goodall Pawel L. Urban
Hydrodynamic chromatography (HDC) is a simple technique for separating particles of different size, from molecules to biological cells. Read More
Choosing a LIMS: Configuration vs Customization
Thursday, September 28, 2017
Simon Wood
When choosing a LIMS, users should consider two distinct methodologies: configuration and customization. Read More
Why Centrifugal Partition Chromatography is a Better Way to Extract Cannabidiol for Medical Research
Tuesday, September 05, 2017
Gregoire Audo
An alternative method for purifying cannabidiol and other cannabis extracts for research use is centrifugal partition chromatography Read More
Automated Glucose Control
Tuesday, September 05, 2017
Stuart Tindal Sebastian Ruhl Diana Dreiling
A bioreactor control system was used for glucose feed control. Read More
Statistics in the Laboratory: The Minimum Consistently Detectable Amount
Tuesday, September 05, 2017
Stanley N. Deming
In the previous column we discussed the limit of detection LD, the minimum signal strength above which we can be confident that analyte is present, but with a small false positive risk a that analyte ... Read More
Rethinking Ultrapure Water
Tuesday, September 05, 2017
Véronique Fontalbat
With an intelligently designed water purification system, each step of the ultrapure water workflow can be improved for great efficiency, ease of data management, and improved sustainability. Read More
A Virtual Instrument System for Testing the Validity of Drugs
Monday, September 04, 2017
Xun Gong Wen Wu Qijun Wu Cheng Cai
A virtual instrument system for measuring the validity period of drugs enhances the performance of spectrophotometers. Read More
Three-Dimensional Co-Culture More Closely Mimics in vivo Interactions of Breast Cancer to Aid Drug Discovery
Wednesday, July 26, 2017
Lubna Hussain Ying Nie Krista Garner
Human mammary epithelial cells and human mammary fibroblasts can be successfully grown in a 3-D co-culture system to mimic the heterotypic interactions of breast cancer cells and stromal cells in vivo... Read More
Top-Down Proteomics: An Emerging Technology Propelled by Mass Spectrometry
Wednesday, July 26, 2017
Rohan A. Thakur
Rapid developments in mass spectrometry technology facilitate innovative solutions to the challenges in top-down proteomics. Read More