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Title
Differential Response of Breast Cancer Cells Cultured in 2-D Versus 3-D to Estrogen Receptor-Targeting Therapeutics
Wednesday, August 07, 2019
Erin Edwards
Thomas S. Villani
Graeme Gardner
Michael T. Johnson
Elin Agoston
A comparison of 2-D and 3-D breast cancer cell culture models reveals that culture method affects estrogen receptor expression.
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Theory and Practical Applications of Automation Solutions in Analytical Measurements
Wednesday, July 24, 2019
Heidi Fleischer
Kerstin Thurow
Automated systems for sample preparation and analytical measurements must follow special protocols due to their complex process structure with multiple subprocesses.
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Powering Preclinical Imaging With Multi-Modal Positron Emission Tomography
Friday, June 07, 2019
Sonica Van Wyk
Multi-modal systems make it simple for researchers to combine the benefits of PET imaging with CT, SPECT, and MRI technology for optimal imaging results.
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With Smart Automation, Clinical Labs Can Generate Higher-Quality Results in Less Time
Friday, January 11, 2019
Adrian Russell
Automation streamlines operations and gives technicians more time to develop assays and evaluate new platforms that can help improve patient outcomes.
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How to Choose the Right Liquid Handling Automation Platform
Friday, January 11, 2019
Hal Wehrenberg
This article discusses some of the key points to consider when choosing a liquid handling platform for your laboratory.
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Delving Deeper Into the Proteome With Novel Mass Spectrometry Methods
Tuesday, August 07, 2018
Gary Kruppa
Scarlet Koch
The integration of a novel separation technique and application of a sophisticated scanning method has enabled researchers to dig even deeper into the proteome.
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Centrifugation: Best Practices for Reliable, Reproducible Results
Wednesday, February 14, 2018
Hugh Tansey
Laboratories can benefit from advances in centrifuge functionality and performance, as well as ergonomics and ease-of-use.
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A Blood Separation Device That Eliminates Centrifugation and Reduces Preanalytical Errors and Turnaround Times
Friday, February 09, 2018
Darren Lee
Clinical diagnostic testing laboratories are under increased pressure to continually provide accurate results for each patient tested while reducing turnaround times (TATs).
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A Portable CGE System for Cell Free DNA Detection
Monday, January 29, 2018
Varouj Amirkhanian
Eric Tsai
Alice Lin
Geoffrey Routh
A capillary gel electrophoresis system provides cost-effective cfDNA analysis for the noninvasive detection of cancer and prenatal genetic testing.
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Isothermal Titration Calorimetry: An Indispensable Tool for Biological Pathway Research and Drug Development
Monday, October 02, 2017
Verna Frasca
As our knowledge of the genetic and molecular basis of disease continues to grow, drug development programs focus increasingly on those proteins associated with disease states.
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Top-Down Proteomics: An Emerging Technology Propelled by Mass Spectrometry
Wednesday, July 26, 2017
Rohan A. Thakur
Rapid developments in mass spectrometry technology facilitate innovative solutions to the challenges in top-down proteomics.
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Long-Range Genomics Is Reviving a Lost Art
Wednesday, July 26, 2017
Chris Boles
The instrument described here was designed to treat DNA gently enough that users can prepare libraries of extremely large fragments directly from blood samples, bacterial and tissue cultures, or other...
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Manufacturing Considerations for IVD Reagents Used in Clinical Chemistry and Special Chemistry Laboratories
Tuesday, July 25, 2017
Robert J. Janetschek
Julia Nisbet-Fahy
Andrew Whitehouse
To produce diagnostic reagents that meet current and future demands requires a knowledge, understanding, and appreciation of the various reagents used for clinical testing applications.
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An Effective Treatment Strategy for Cytokine Storm in Severe Influenza
Tuesday, July 25, 2017
Erin Murphy
Despite the use of vaccines and antiviral therapies such as oseltamivir, severe influenza kills thousands to tens of thousands of Americans each year.
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A Field-Portable Bioanalysis System
Tuesday, July 11, 2017
Varouj Amirkhanian
Eric Tsai
Alice Lin
A portable bioanalysis system provides high resolution and high detection sensitivity, and is a cost-effective solution for the field detection of pathogens.
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A New Era in Filtered Fume Enclosure Safety
Wednesday, June 07, 2017
The latest ductless filtered fume enclosures are a vital resource in the safe and effective operation of modern industrial, educational, hospital, forensic, and pharmaceutical scientific laboratories.
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A Redesigned Confocal Microscope for Super-Resolution Microscopy
Tuesday, May 09, 2017
Erik Manders
Peter Drent
Ronald Breedijk
A simple optical redesign converts a standard confocal microscope to a super-resolution microscope.
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Liquid Handling Uses Acoustic Droplet Ejection for Improved Results
Monday, May 08, 2017
Mark Fischer-Colbrie
Acoustic drop ejection systems can pave the way for entirely new applications, bringing higher throughput and greater flexibility to many areas of biology.
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
Friday, November 04, 2016
Michael Kowalski
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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High-Throughput Drug Screening of Multicellular Tumor Spheroids
Tuesday, September 27, 2016
Ana Maria P. Pardo
Hannah J. Gitschier
David H. Randle
Terry Riss
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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