October 2010
Volume 42, Number 10
UV-VIS spectrophotometry and TOC analysis can be used for cleaning validation in pharmaceutical facilities, as discussed in the October issue. Also featured is an article on the role of vibrational circular dichroism in early drug discovery, and Quality of Design of chromatographic methods.
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Table of Contents
Chester Bowen
The application of dried blood spots (DBS) for the storage, shipment, and quantification of xenobiotics has been gaining popularity in recent years. The invention of this technology can be attributed ...
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Fraser McNeil-Watson, Michael Kaszuba
Understanding and controlling the characteristics of proteins in solution is fundamental to predicting their aggregation behavior and determining appropriate conditions for storage, crystallization, ...
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Richard H. Clifford
Quality control and product safety are paramount in the manufacture of pharmaceutical products. Therefore, it is essential that substances other than those approved for a product are not included with...
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Alexey Makarov, Zhi Chen, Fred Chan, Rekha Bhashyam, Rosario LoBrutto, Raju Vegesna
The introduction of Quality by Design, a systematic approach to product and process design and development, has shifted the paradigm in HPLC methods development from a retrospective approach to a ...
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Feng Qiu, Yingru Zhang, Janet Caceres-Cortes, Michael D. Reily
Chirality is an intrinsic property of living matter, and many biological molecules exhibit a preference for one enantiomer over another. As such, chirality has been introduced into more than half of ...
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David Coleman, Lynn Vanatta
There are indeed statistical issues related to blanks. To set the stage, a discussion of the concept itself will be helpful.
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